Protective mechanism of adenosine to the arterial endothelial injury induced by hydrogen dioxide
发布时间：2025-04-30
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- 发布时间：
- 2025-04-30
- 论文名称：
- Protective mechanism of adenosine to the arterial endothelial injury induced by hydrogen dioxide
- 发表刊物：
- Biol Pharm Bull
- 摘要：
- This study was designed to examine the in vitro effects of adenosine (Ado) on hydrogen peroxide-induced endothelial dysfunction in rats. Endothelial dysfunction was induced by exposing isolated rat mesenteric arteries to hydrogen peroxide (0.5 mM) for 12 h using an organ culture system. The protective effects of adenosine were tested by exposing isolated mesenteric arteries to adenosine (3 x 10(-7) mol/l, 10(-6) mol/l, 3 x 10(-6) mol/l)+hydrogen peroxide (0.5 mM) for 12 h. This exposure to hydrogen peroxide induced a significant concentration-dependent inhibition of endothelium-dependent relaxation (EDR). Coculture of segments of mesenteric artery with adenosine (3 x 10(-7), 10(-6), and 3 x 10(-6) mol/l) attenuated the hydrogen peroxide-induced impairment of vasorelaxation. This impairment was accompanied by a reduction in nitrite/nitrate, nitric oxide (NO) synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and an increasing in malondislehyde (MDA) and lactate dehydrogenase (LDH) activities in the aorta. These results indicate that adenosine can be used to attenuate hydrogen peroxide-induced endothelial dysfunction, an effect that may be related to antioxidation, thus enhancing NO production by preventing the decrease in NOS.
- 合写作者：
- Lu J, Zhu SM, Zang WJ* et al
- 卷号：
- 30(7)
- 页面范围：
- 1206-1211
- 是否译文：
- 否
- 发表时间：
- 2007-07-19