西安交通大学

基础医学院

转化医学研究院心血管研究所

陕西省西安市中国西部科技创新港21号楼泓仁楼

• 2025-2028   国家自然科学基金面上项目，主持。

  2024-2025   企业横向课题-心肌再生修复XXX，主持

  2024-2026   陕西省杰出青年基金项目，主持。

  2019-2024   科技部重点专项，子课题负责人。

  2020-2023   国家自然科学基金面上项目，主持。

  2019-2022   陕西省人社厅重点项目，主持。

  2018-2021   陕西省高层次人才计划青年项目，主持。

  2018-2024   西安交通大学“青年拔尖人才计划”A类项目, 主持。

  2013-2015   美国心脏协会博士后基金, 主持。

  2011-2016   美国国立卫生研究院R1项目, 参与。

器官发生与损伤修复机制

• 心脏发育

• 心脏损伤修复机制

• 器官纤维化机制

王一东，男，博士，西安交通大学基础医学院教授，西安交通大学第一附属医院特聘教授，博士生导师，陕西省杰出青年基金和青年人才项目获得者，入选西安交通大学A类青年拔尖人才计划。主要从事组织器官发育和损伤修复机制研究，重点关注心脏和肝脏的损伤修复机制。共发表SCI论文30篇，其中以第一（含共一）/通讯作者在J Hepatol、Eur Heart J、Nat Cell Biol、Nat Commun等国际权威期刊发表论文18篇。主持/参与国自然面上项目、科技部重点研发项目、陕西省杰出青年基金项目、陕西省重点项目、美国心脏协会博士后基金等多项。现任中国动物学会发育生物学专业委员会委员，Front Cell Dev Biol 杂志特邀副编辑。

• 2023-至今   西安交通大学第一附属医院，特聘教授
• 2018-至今          西安交通大学基础医学院，教授
• 2016-2018       美国阿尔伯特爱因斯坦医学院，研究助理
• 2012-2016       美国阿尔伯特爱因斯坦医学院，博士后
• 2008-2011       美国阿尔伯特爱因斯坦医学院，访问学者
• 2006-2011       四川大学生物治疗国家重点实验室，博士研究生
• 2002-2006       西南交通大学生命科学与工程学院，本科

1. Huahua Liu^#, Jinling Dong^#, Shuang Liu^#, Yuru Luo, Yuan Fang, Hongyu Su, Weihao Xue, Rui Zhou, Wenjun Huang, Baochang Lai, Ying Xiong, Shuangshuang Wang, Lingli Liang, Zhen Wang, Donghong Zhang, Lianpin Wu, Yanmin Zhang, Bin Zhou, John Y-J Shyy*, Zuyi Yuan*, Yidong Wang*. Regulation of heart regeneration by LSD1 through suppressing CEND1.Theranostics. 2025.
2. Yuru Luo ^#, Shuang Liu^#, Yuan Fang, Hongyu Su, Jinling Dong, Baochang Lai, Zhen Wang, Donghong Zhang*, Yidong Wang*. Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice. Biology of Reproduction. 2025.
3. Shan He^#, Yuru Luo^#, Wangge Ma^#, Xiaoke Wang^#, Chengrong Yan, Wenyang Hao, Yuan Fang, Hongyu Su, Baochang Lai, Junhui Liu, Ying Xiong, Ting Bai, Xiaoyong Ren, Enqi Liu, Hua Han, Yue Wu*, Zuyi Yuan*, Yidong Wang*. Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis. Journal of Hepatology. 2024.
4. Huahua Liu^#, Rui Zhou^#, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J Shyy, Bin Zhou, Zuyi Yuan*, Yidong Wang*. Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024.
5. Huahua Liu^#, Pengfei Lu^#, Shan He, Yuru Luo, Yuan Fang, Sonia Benkaci, Bingruo Wu, Yidong Wang*, Bin Zhou*. β-Catenin regulates endocardial cushion growth by suppressing p21. Life Science Alliance. 2023.
6. Bingruo Wu^#, Brian Wu^#, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice Morrow, Yidong Wang*, Bin Zhou*. Crk and Crkl are required in the endocardial lineage for heart valve development. Journal of the American Heart Association. 2023.
7. Wangge Ma^#, Wei Zhang^#, Huahua Liu, Benheng Qian, Rongguang Lai, Zijun Yao, Yidong Wang, Yang Yan*, Zuyi Yuan*. Plasma Cell-free DNA is a potential biomarker for diagnosis of calcific aortic valve disease. Cardiology. 2023.
8. Pengfei Lu, Bingruo Wu, Yidong Wang, Megan Russell, Yang Liu, Daniel J. Bernard, Deyou Zheng, Bin Zhou*. Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis. Developmental Cell. 2023.
9. Benheng Qian, Kexin Li, Xiaoying Lou, Ye Guo, Yidong Wang*, Lianpin Wu*, Donghong Zhang*. Plasma Cell-Free DNA as a Novel Biomarker for the Diagnosis and Monitoring of Atherosclerosis. Cells. 2022.
10. Pengfei Lu, Ping Wang, Bingruo Wu, Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng*, Bin Zhou*. A SOX17-PDGFB signaling axis regulates aortic root development. Nature communications. 2022.
11. Pengfei Lu^#; Yidong Wang^#; Yang Liu; Yifeng Wang; Bingruo Wu; Deyou Zheng, Richard P. Harvey; Bin Zhou*; Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signaling. Nature Cell Biology. 2021.
12. Yidong Wang*; Yuan Fang; Pengfei Lu; Bingruo Wu; Bin Zhou*. NOTCH signaling in aortic valve development and calcific aortic valve disease. Frontiers in Cardiovascular Medicine. 2021.
13. Yidong Wang*, Pengfei Lu, Liping Jiang, Bingruo Wu, Bin Zhou*. Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1. Cardiovascular Research. 2020.
14. Terence Gee，Emily Farrar，Yidong Wang，Bingruo Wu，Kevin Hsu，Bin Zhou，Jonathan Butcher*. NFκB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type–Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve. Arteriosclerosis Thrombosis and Vascular Biology. 2020.
15. Dongying Chen, Xiaolong Zhu, Natalie Kofler, Yidong Wang, Bin Zhou, Michael Simons*. FRS2-dependent cell fate transition during endocardial cushion morphogenesis. Developmental Biology. 2019.
16. Yang Liu, Pengfei Lu, Yidong Wang, Bernice Morrow, Bin Zhou, Deyou Zheng*. Spatiotemporal gene Coexpression and regulation in mouse cardiomyocytes of early cardiac morphogenesis. Journal of the American Heart Association. 2019.
17. Yidong Wang*^,#, Pengfei Lu^#, Bingruo Wu, Bernice Morrow, Bin Zhou*. NOTCH maintains developmental cardiac gene network through WNT5A. Journal of Molecular Cellular Cardiology. 2018.
18. Yidong Wang*, Pengfei Lu, Bingruo Wu, Dario F. Riascos-Bernal, Nicholas E.S Sibinga, Tomas Valenta, Konrad Basler, Bin Zhou*. Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation. Journal of Molecular Cellular Cardiology. 2018.
19. Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Feng Xiao, Shweta Vashney, Zhenwu Zhuang, Nicholas E.S Sibinga, Nikolaos G. Frangogiannis, Kitsis Richard, David Sharp, Pamela Stanley, Bin Zhou*. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nature Communications. 2017.
20. Yidong Wang, Bingruo Wu, Emily Farrar, Wendy Lui, Pengfei Lu, Donghong Zhang, Christina M. Alfieri, Kai Mao, Ming Chu, Di Yang, Di Xu, Michael Rauchman, Verdon Taylor, Simon Conway, Katherine E. Yutzey, Jonathan T. Butcher, Bin Zhou*. Notch-Tnf signaling is required for development and homeostasis of arterial valves. European Heart Journal. 2017.
21. Bingruo Wu^#, Yidong Wang^#, Feng Xiao, Jonathan T. Butcher*, Katherine E. Yutzey*, Bin Zhou*. Development mechanisms of aortic valve malformation and disease. Annual Review of Physiology. 2017.