王大权

Date:

2025-04-30

Title of Paper:

Multifunctional Polyphosphazene-Coated Multi-Walled Carbon Nanotubes for the Synergistic Treatment of Redox-Responsive Chemotherapy and Effective Photothermal Therapy

Journal:

Polymer Chemistry

Summary:

It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent foreffective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligiblyaffected normal cells. Hence, this DDS demonstrates the proof-ofconcept for effective chemo-photothermal synergistic therapy

Co-author:

Wang Daquan#; Ren Yibo#; Shao Yongping; Meng Lingjie*

Volume:

8(45)

Page Number:

6938-6942

Translation or Not:

No

Date of Publication:

2017-10-01