Facile Preparation of Doxorubicin- Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N‑Vinyl Pyrrole) for Targeted Synergistic Chemo- Photothermal Cancer Treatment
Release Time:2025-04-30
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- Date:
- 2025-04-30
- Title of Paper:
- Facile Preparation of Doxorubicin- Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N‑Vinyl Pyrrole) for Targeted Synergistic Chemo- Photothermal Cancer Treatment
- Journal:
- Bioconjugate Chemistry
- Summary:
- We developed a bifunctional nanoplatform for
targeted synergistic chemo−photothermal cancer treatment. The
nanoplatform was constructed through a facile method in which
poly(N-vinyl pyrrole) (PVPy) was coated on cut multiwalled carbon
nanotubes (c-MWNTs); FA-PEG-SH was then linked by thiol−ene
click reaction to improve the active targeting ability, water
dispersibility, and biocompatibility and to extend the circulation
time in blood. The PVPy shell not only enhanced the photothermal
effect of c-MWNTs significantly but also provided a surface that
could tailor targeting molecules and drugs. The resulting MWNT@
PVPy-S-PEG-FA possessed high drug-loading ratio as well as pHsensitive unloading capacity for a broad-spectrum anticancer agent,
doxorubicin. Owing to its outstanding efficiency in photothermal
conversion and ability in targeted drug delivery, the material could
potentially be used as an efficient chemo−photothermal therapeutic nanoagent to treat cancer.
- Co-author:
- Wang Daquan; Ren Yibo; Shao Yongping; Yu Demei; Meng Lingjie*
- Volume:
- 28(11)
- Page Number:
- 2815-2822
- Translation or Not:
- No
- Date of Publication:
- 2017-10-02