王大权

Date:

2025-04-30

Title of Paper:

Stepwise Growth of Gold Coated Cancer Targeting Carbon Nanotubes for The Precise Delivery of Doxorubicin Combined with Photothermal Therapy

Journal:

Journal of Materials Chemistry B

Summary:

Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimodal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and photothermal therapy for localized cancer treatment. The agent was constructed layer-by-layer from polypyrrole and gold nanoparticles on multi-walled carbon nanotubes. The gold
surface was modified with tumor targeting folic acid terminated PEGylated chains, which also provide waterdispersibility, biocompatibility and should extend the half-life in blood. The material has a high loading/unloading capacity for the cytotoxic agent doxorubicin. Release of the doxorubicin, combined with the photothermal properties of the material that induces localized hyperthermia, leads to efficient cancer cell death

Co-author:

Wang Daquan#; Hou Chen#; Meng Lingjie*; Long Jiangang; Jing Jiange; Dang Dongfen

Volume:

5(7)

Page Number:

1380-1387

Translation or Not:

No

Date of Publication:

2017-02-04