西安交通大学教师主页管理系统王大权 One-Pot Synthesis of Fluorescent and Cross-Linked Polyphosphazene Nanoparticles for Highly Sensitive and Selective Detection of Dopamine in Body Fluids Home

One-Pot Synthesis of Fluorescent and Cross-Linked Polyphosphazene Nanoparticles for Highly Sensitive and Selective Detection of Dopamine in Body Fluids

Release Time:2025-04-30

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Title of Paper:: One-Pot Synthesis of Fluorescent and Cross-Linked Polyphosphazene Nanoparticles for Highly Sensitive and Selective Detection of Dopamine in Body Fluids

Summary:: Highly cross-linked and monodisperse polyphosphazene (PZS) nanoparticles exhibiting strong fluorescence were prepared by the facile one-pot polycondensation of hexachlorocyclotriphosphazene and 4′,5′-dibromofluorescein (DBF). Fluorescent DBF units were ‘immobilized’ and ‘isolated’ in the cross-linked structures to effectively overcome their concentration-quenching effect and improve their photobleaching properties. The resulting DBF–PZS nanoparticles emitted bright yellow fluorescence at any concentration and exhibited excellent resistance to photobleaching as well as interference from bio-molecules such as proteins, ascorbic acid and uric acid. Intriguingly, the fluorescence of the DBF–PZS nanoparticles was linearly quenched by DA range from 0.5 to 15 μg·mL−1 DA concentration via photoinduced charge transfer. Therefore, DBF–PZS nanoparticles represent a simple but effective, highly sensitive and selective detection method with a direct read out for DA in biological fluids.