王然  (副教授)

博士生导师 硕士生导师

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入职时间：2024-01-31

学历：硕博连读

性别：男

学位：博士

在职信息：在职

学科：生物学

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(5.)Scientific Research

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First/Co-first author publication:

  1. Ran Wang #, Xianfa Yang #, Jiehui Chen #, Lin Zhang #, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P.L. Tam *, Naihe Jing *. Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nature Communications 2023, 14(1): 5675

  1. Ran Wang, Guangdun Peng, Patrick P L Tam, Naihe Jing *. Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Study. Genomics, Proteomics & Bioinformatics 2023, 21(1): 13-23.

  1. Zhiping Rao #, Ran Wang # (co-first author), Sanlan Li #, Yuhan Shi, Licun Mo, Su'e Han, Jiacheng Yuan, Naihe Jing *, Leping Cheng *. Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion. Stem Cell Reports 2021, 16(3): 534-547.

  1. Wenqian Song #, Ran Wang # (co-first author), Weimin Jiang, Qi Yin, Guangdun Peng, Ruikai Yang, Qing Cissy Yu, Jianfeng Chen, Jingsong Li, Tom H Cheung, Naihe Jing, Yi Arial Zeng *. Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Research 2019, 29(4): 206-220.

  1. Guang Yang #, Changyang Zhou #, Ran Wang # (co-first author), Shisheng Huang, Yu Wei, Xianfa Yang, Yajing Liu, Jianan Li, Zongyang Lu, Wenqin Ying, Xiajun Li, Naihe Jing, Xingxu Huang *, Hui Yang *, Yunbo Qiao *. Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development. Cell Reports 2019, 26(2): 302-312.

  1. Xianfa Yang #, Ran Wang # (co-first author), Xiongjun Wang #, Guoqing Cai, Yun Qian, Su Feng, Fangzhi Tan, Kun Chen, Ke Tang, Xingxu Huang *, Naihe Jing *, Yunbo Qiao *. TGFbeta signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs. Journal of Molecular Cell Biology 2018, 10(3): 216-228.

  1. Yuanyuan Li #, Ran Wang # (co-first author), Nan Qiao, Guangdun Peng, Ke Zhang, Ke Tang, Jing-Dong J Han *, Naihe Jing *. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. Journal of Biological Chemistry 2017, 292(48): 19590-19604.

  1. Yunbo Qiao #, Ran Wang # (co-first author), Xianfa Yang, Ke Tang, Naihe Jing *. Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. Journal of Biological Chemistry 2015, 290(4): 2508-2520.

Co-author publication:

  1. Xiaoxiao Wang #, Yunlong Xiang #, Yang Yu #, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie *, Lei Li *. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research 2021, 31(5): 526-541.

  1. Ke Zhang #, Fang Yu #, Jian Zhu #, Sue Han #, Jiehui Chen #, Xuanyuan Wu #, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He *, Naihe Jing *, Ke Tang *. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation. Cell Reports 2020, 31(3): 107521.

  1. Guangdun Peng #, Shengbao Suo #, Guizhong Cui #, Fang Yu #, Ran Wang, Jun Chen, Shirui Chen, Zhiwen Liu, Guoyu Chen, Yun Qian, Patrick P L Tam, Jing-Dong J Han *, Naihe Jing *. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature 2019, 572(7770): 528-532.

  1. Ting Zhang #, Wei Ke #, Xuan Zhou #, Yun Qian, Su Feng, Ran Wang, Guizhong Cui, Ran Tao, Wenke Guo, Yanhong Duan, Xiaobing Zhang, Xiaohua Cao, Yousheng Shu, Chunmei Yue *, Naihe Jing *. Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease. Stem Cell Reports 2019, 13(6): 1022-1037.

  1. Xianfa Yang #, Boqiang Hu #, Jiaoyang Liao #, Yunbo Qiao #, Yingying Chen, Yun Qian, Su Feng, Fang Yu, Ji Dong, Yu Hou, He Xu, Ran Wang, Guangdun Peng, Jinsong Li *, Fuchou Tang *, Naihe Jing *. Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Research 2019, 29(11): 911-926.

  1. Berna Sozen #, Gianluca Amadei #, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz *. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nature Cell Biology 2018, 20(8): 979-989.

  1. Neophytos Christodoulou #, Christos Kyprianou #, Antonia Weberling, Ran Wang, Guizhong Cui, Guangdun Peng, Naihe Jing, Magdalena Zernicka-Goetz *. Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nature Cell Biology 2018, 20(11): 1278-1289.

  1. Xianfa Yang #, Boqiang Hu #, Yu Hou #, Yunbo Qiao #, Ran Wang, Yingying Chen, Yun Qian, Su Feng, Jun Chen, Chang Liu, Guangdun Peng, Fuchou Tang *, Naihe Jing *. Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages. Cell Research 2018, 28(5): 593-596.

  1. Chang Liu, Ran Wang, Zhisong He, Pierre Osteil, Emilie Wilkie, Xianfa Yang, Jun Chen, Guizhong Cui, Wenke Guo, Yingying Chen, Guangdun Peng, Patrick P L Tam, Naihe Jing *. Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports 2018, 11(1): 43-57.

  1. Guizhong Cui #, Shengbao Suo #, Ran Wang, Yun Qian, Jing-Dong J Han *, Guangdun Peng *, Patrick P L Tam *, Naihe Jing *. Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth & Differentiation 2018, 60(8): 463-472.

  1. Xue Han #, Sai Luo #, Guangdun Peng #, J Yuyang Lu, Guizhong Cui, Lichao Liu, Pixi Yan, Yafei Yin, Wei Liu, Ran Wang, Jiejie Zhang, Shanshan Ai, Zai Chang, Jie Na, Aibin He, Naihe Jing *, Xiaohua Shen *. Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. Journal of Molecular Cell Biology 2018, 10(2): 175-178.

  1. Su Feng #, Can Xing #, Tingyu Shen #, Yunbo Qiao, Ran Wang, Jun Chen, Jiaoyang Liao, Zhuo Lu, Xiong Yang, Saber Mohamed Abd-Allah, Jinsong Li, Naihe Jing *, Ke Tang *. Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Scientific Reports 2017, 7(1): 5282

  1. Guangdun Peng #, Shengbao Suo #, Jun Chen #, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P L Tam, Jing-Dong J Han *, Naihe Jing *. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell 2016, 36(6): 681-697.

  1. Yunbo Qiao #, Xiongjun Wang #, Ran Wang, Yuanyuan Li, Fang Yu, Xianfa Yang, Lu Song, Guoliang Xu, Y Eugene Chin *, Naihe Jing *. AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation. Cell Discovery 2015, 1: 15017.

  1. Lingyu Li #, Lu Song #, Chang Liu, Jun Chen, Guangdun Peng, Ran Wang, Pingyu Liu, Ke Tang, Janet Rossant, Naihe Jing *. Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. Journal of Molecular Cell Biology 2015, 7(5): 455-465.