The major focus of our group is to unravel the molecular mechanisms that underline the processes of cell growth and differentiation relate to intestinal barrier. Intestinal bacteria could translocate into liver by portal vein in the normal circumstance and this phenomenal will increase when intestinal barrier impair and/or intestinal bacteria over growth. Our various ongoing projects relate to understanding the differentiation process in the contexts of:

1. Normal development

2. Homeostasis within the adult

3. Pathological conditions such as starvation, cancer, aging, diabetes and alcohol consumption.