周琨

      有机光催化材料凭借其可调的氧化还原特性与电子结构，在疾病治疗领域展现出令人瞩目的潜力。其核心魅力在于“一分子，多功能”——在光照激发或电子转移后，可精准、高效地生成多种活性氧（ROS），从而为光动力、声动力及光催化等多模态治疗体系提供全新平台。这类材料兼具良好的可修饰性和电子活性，不仅成为探索能量转换与催化机制的理想载体，也为新型光敏剂与气体治疗策略的开发提供了全新范式，为实现精准的诊疗一体化开辟了新路径。目前系统开展以下几个方面的研究：

1. 光催化调控生物体系的氧化还原平衡

2. 光/声敏剂激发态调控与机制解析

3. 可穿戴诊疗分析设备的开发

4. 高灵敏AIE荧光探针的开发及药物评估与示踪

       研究贯穿“分子设计—机制解析—生物应用—疗效评估”全创新链条，旨在开发新一代智能诊疗一体化系统，并拓展至药物示踪、可穿戴分析设备等前沿应用场景。

       如果你对“发光材料+催化医学”这一交叉领域充满好奇，有志于探索化学、材料与生命科学的深度融合，欢迎加入我们，一起点亮生命过程中的未知细节！

1. Zhou, K., Du, L., Ding, R., Xu L., Shi, S., Wang, S., Wang, Z., Zhang, G., He, G.,* Zhao, Z.,* Tang, B. Z.* Photocatalytic therapy via photoinduced redox imbalance in biological system Nat. Commun. 2024, 15, 10551. (IF: 14.7)

2. Zhou, K.; Yu, Y.; Xu, L.; Wang, S.; Li, Z.; Liu, Y.; Kwok, R. T. K.; Sun, J.; Lam, J. W. Y.; He, G.,* Zhao, Z.,* Tang, B. Z.* Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy. ACS Nano 2024, 18, 29930. (IF: 15.8)

3. Zhou, K., Wang, S., Xu L., Li, H., Wang, Y., Qiu, Z., Zhang, G., Zhao, Z.,* Tang, B. Z.* AIEgen-based smart system for fungal-infected wound monitoring and on-demand photodynamic therapy. Matter 2023, 6, 3449. (IF: 18.9)

4.  Zhou, K.; Chigan, D.; Xu, L.; Liu, C.; Ding, R.; Li, G.; Zhang, Z.; Pei, D.; Li, A.; Guo, B.; Yan, X.; He, G*. Anti-Sandwich Structured Photo-Electronic Wound Dressing for Highly Efficient Bacterial Infection Therapy. Small 2021, 17, e2101858. (IF: 13.3)

5. Zhou, K.; Qiu, X.; Xu, L.; Li, G.; Rao, B.; Guo, B.; Pei, D.; Li, A.; He, G*., Poly(selenoviologen) Assembled Upconversion Nanoparticles for Low Power Single NIR Light Triggered Synergistic Photodynamic and Photothermal Antibacterial Therapy. ACS Appl. Mater. Interfaces 2020, 12, 26432. (IF: 9.5)

6. Zhou, K.; Tian, R.; Li, G.; Qiu, X.; Xu, L.; Guo, M.; Chigan, D.; Zhang, Y.; Chen, X.; He, G.*, Cationic Chalcogenoviologen Derivatives for Photodynamic Antimicrobial Therapy and Skin Regeneration. Chem. Eur. J. 2019, 25, 13472. (Cover Paper, IF: 4.3)

7. Ma, W.; Ding, R.; Wang, S.; Wang, Z.; Xu, L.; Zhou, K.*; Ma, J.*; He, G.*, On-Site Visualized Periodontitis Screening via Dual-Signal H₂S Probe. Adv Healthc. Mater. 2025, e02710. (corresponding author, IF: 9.6)

8. Lyu, X.; Hu, Y.; Shi, S.; Wang, S.; Li, H.; Wang, Y.; Zhou, K.*, Hydrogel Bioelectronics for Health Monitoring. Biosensors 2023, 13, 815. (corresponding author, IF: 5.7)

9. Zhang, W.; Feng, X.; Zhang, C.; Jia, Q.; Liu, X.; Zhou, K.*, Activity of N–H in phenothiazine derivatives: synthesis and applications in fluoride ions sensing and electrochromism. J. Mater. Chem. C 2023, 11, 2949. (corresponding author, IF: 6.4)

10. Zhang, C.; Wang, Z.; Chen, T.; Tang, M.; Zhang, J.; Jian, J.; Wang, Y.; Zhou, K.*; Zhang, X.*, Methylamine Gas Sensor Based on Fluorescent Perovskite Nanocrystal Nanofibers Incorporating Aggregation-Induced Emission Materials. ACS Applied Nano Materials 2024, 7, 17329. (corresponding author, IF: 6.4)

11. Cheng, Y.; Zhou, K.†; Chen, Y.; Mei, Y.; Wang, Z.; Wang, W. J.; Li, H.; Chen, Y.; Liu, Z.; Zeng, J.; Luo, Y.; He, D.; Zhao, Z.; Tang, B. Z.*, Concurrent Ferroptosis and Pyroptosis Induced by a Dual-Organelle-Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy. Angew. Chem., Int. Ed. 2025, 64, e202509783. (co-first author, IF: 16.6)

12. Li, G.†; Zhou, K.†; Sun, Q.; Ma, W.; Liu, X.; Zhang, X.; Zhang, L.; Rao, B.; He, Y. L.; He, G.*, Bacteria-Triggered Solar Hydrogen Production via Platinum(II)-Tethered Chalcogenoviologens. Angew. Chem., Int. Ed. 2022, 61, e202115298. (co-first author, IF: 16.6)

13. Xu, L.; Zhou, K.†; Ma, H.; Lv, A.; Pei, D.; Li, G.; Zhang, Y.; An, Z.; Li, A.; He, G.*, Ultralong Organic Phosphorescent Nanocrystals with Long-Lived Triplet Excited States for Afterglow Imaging and Photodynamic Therapy. ACS Appl. Mater. Interfaces 2020, 12, 18385. (co-first author, IF: 9.5)

14. Xu, L.; Zhou, K.†; Qiu, X.; Rao, B.; Pei, D.; Li, A.; An, Z.; He, G.*, Tunable ultralong organic phosphorescence modulated by main-group elements with different Lewis acidity and basicity. J. Mater. Chem. C 2020, 8, 14740. (Cover Paper, co-first author, IF: 6.4)

15. Wang, S.†; Zhou, K.†; Lyu, X.; Li, H.; Qiu, Z.*; Zhao, Z.*; Tang, B. Z.*, The Bioimaging Story of AIEgens. Chemical & Biomedical Imaging 2023, 1, 509. (Cover Paper, co-first author，IF: 5.7)

    
    

We are always looking for new graduate students and postdoc to join our research team.

• 本  科 生——欢迎来实验室交流学习1-3名。

• 研  究 生——每年招收硕士研究生1名，博士研究生1名。

• 博  士 后——招聘荧光材料合成、光催化、生物传感器及药学等方向相关的优秀博士后 （A类入选者年收入30万/年，并享受学校相关的待遇）

• 青年教师——欢迎材料、药学背景的博士研究生加盟西安交通大学 药学院

      （相关政策见 https://pharm.xjtu.edu.cn/info/1160/3993.htm）

欢迎感兴趣的同学来信咨询。

联系人：周琨

Email: zhoukun@xjtu.edu.cn。