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张宇

副教授 博士生导师 硕士生导师

  • 学历: 硕博连读
  • 学位: 博士

论文专著

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1Yu Zhang, Shufeng Feng, Gaohang Yi, Shujun Jin, Yongxin Zhu, Xiaoxiao Liu, Jinsong Zhou, Hai Li. Genome-wide screening reveals oncolytic mechanism of newcastle disease virus on colonic carcinoma. Viruses. 2025, 17(8): 1043.

2Zhang Y, Li X, Tian H, Xi M, Zhou J, Li H. p53 Activation Facilitates Transdifferentiation of Human Cardiac Fibroblasts into Endothelial Cells. Tissue Eng Part A. 2024, 30(7-8): 330-339. 

3Zhang Y, Li X, Xing J, Zhou J, Li H. Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules. Biomedicines. 2023, 11(11): 2913. 

4Li X, Liu X, Cui L, Liu Z, Zhang Y, Li H. How to Break through the Bottlenecks of in Ovo Vaccination in Poultry Farming. Vaccines. 2024, 12(1): 48. 

5Yang Yu, Xuechun Li, Yimei Li, Renyue Wei, Hai Li, Zhonghua Liu, Yu Zhang. Derivation and characterization of endothelial cells from porcine induced pluripotent stem cells. Int J Mol Sci. 2022, 23(13): 7029. 

6Xuechun LiYang YuRenyue WeiYimei LiJiawei LvZhonghua LiuYu Zhang. In vitro and in vivo study on angiogenesis of porcine induced pluripotent stem cell-derived endothelial cells. Differentiation. 2021, 120:10-18. 

7Yan Li, Shuang Wu, Yang Yu, Heng Zhang, Renyue Wei, Jiawei Lv, Mingming Cai, Xu Yang, Yu Zhang, Zhonghua Liu. Derivation of porcine extraembryonic endoderm-like cells from blastocysts. Cell Proliferation. 2020, 53(4):e12782. 

8Li Y, Wu S, Li X, Guo S, Cai Z, Yin Z, Zhang Y, Liu Z. Wnt signaling associated small molecules improve the viability of pPSCs in a PI3K/Akt pathway dependent way. Journal of Cellular Physiology. 2020, 235(7-8): 5811-5822. 

9Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z. Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system. Journal of Veterinary Science. 2020, 21(1):e9. 

10Zhang Y, Zhu C, Sun B, Lv J, Liu Z, Liu S, Li H. Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells. Cellular Physiology and Biochemistry. 2017; 42(3):1177-1191. 

11Yu Zhang, Ran Xu, Jianyu Xing, Renyue Wei, Jiawei Lv, Shichao Liu, Jiuhui Shi, Zhonghua Liu. Osteogenic differentiation from induced pluripotent stem cells via a three-dimensional culture method. J Biomater Tiss Eng. 2017, 7(6):448-457. 

12Zhang YMa JLi HLv JWei RCong YLiu Z. bFGF signaling-mediated reprogramming of porcine primordial germ cells. Cell Tissue Res. 2016; 364(2):429-441. 

13Zhang YLi HWei RMa JZhao YLian ZLiu Z. Endothelial cells regulate cardiac myocyte reorganisation through β1-integrin signalling. Cell Physiol Biochem. 2015; 35(5):1808-1820. 

14Y Zhang, J Xing, Q Ren, J Shi, Z Liu. Effects of BMP4/7 on high-glucose-level induced suppression of osteogenic differentiation of mouse iPS cells. Journal of Biotechnology. 2014; 185S:125. 

15Zhang YLi HLian ZLi N. Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via β1 integrin-PI3K/Akt pathway. Development Growth and Differentiation. 2010; 52(8): 725-733. 

16Zhang YLi HLian ZLi N. Normal fibroblasts promote myodifferentiation of myoblasts from sex-linked dwarf chicken via up-regulation of β1 integrin. Cell Biology International. 2010; 34(11): 1119-1127. 

17Li HZhang YStröse ATedesco DGurova KSelivanova G. Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell Death Differ. 2014; 21(9): 1493-1502. 

18H Li, Y Zhang, G Selivanova. Integrated high throughput analysis identifies AP-1 as a crucial factor of p53-mediated cell fate decision. Journal of Biotechnology. 2014; 185S:89. 

19Li HZhang YZuo SFLian ZXLi N. Effects of methyltestosterone on immunity against Salmonella Pullorum in dwarf chicks. Poultry Science. 2009; 88(12): 2539-2548. 

20Li HZhang YNing ZHDeng XMLian ZXLi N. Effect of selection for phagocytosis in dwarf chickens on immune and reproductive characters. Poultry Science.2008; 87(1):41-49. 

21Backström NLindell JZhang YPalkopoulou EQvarnström ASaetre GPEllegren H. A high-density scan of the Z-chromosome in Ficedula flycatchers reveals candidate loci for diversifying selection. Evolution. 2010; 64(12): 3461-3475. 

22Li Y, Song D, Yu Z, Zhang Y, Liu Z, Yan T. Effect and mechanism of hypoxia on differentiation of porcine-induced pluripotent stem cells into vascular endothelial cells. In Vitro Cell Dev Biol Anim. 2024; 60(1): 9-22. doi: 10.1007/s11626-023-00833-8. 

23Liu Z, Cui L, Li X, Xu L, Zhang Y, Han Z, Liu S, Li H. Characterization of the Effects of Host p53 and Fos on Gallid Alpha Herpesvirus 1 Replication. Genes (Basel). 2023, 14(8): 1615. 

24Zheyi Liu, Xuefeng Li, Lu Cui, Shufeng Feng, Zongxi Han, Yu Zhang, Shengwang Liu, Hai Li. Co-Regulation Mechanism of Host p53 and Fos in Transcriptional Activation of ILTV Immediate-Early Gene ICP4. Microorganisms. 2024; 12(10): 2069. 

25Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z. The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells. J Vet Sci. 2019; 20(3): e23. 

26Zhang X, Xue B, Li Y, Wei R, Yu Z, Jin J, Zhang Y, Liu Z. A novel chemically defined serum- and feeder-free medium for undifferentiated growth of porcine pluripotent stem cells. J Cell Physiol. 2019; 234(9): 15380-15394. 

27Hai T, Cao C, Shang H, Guo W, Mu Y, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H, Yang S, Liu Z, Wei H, Zhao J, Zhou Q, Meng A. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. eLife. 2017; 6: e26248. 

28、于杨,李怡美,伟人悦,柴梦佳,刘忠华,张宇iPSCs来源的血管内皮细胞对小鼠下肢缺血的修复作用研究《中国细胞生物学学报》2021. 43(11): 2117-25. 

29张宇李海孔建铭韩登桥连正兴肌肉发生相关基因的网络调控研究《黑龙江畜牧兽医》 2007. 10:24-6. 

30张宇李海孔建铭蛋源无血清培养基培养类囊胚和鸡、人成纤维细胞的研究《黑龙江畜牧兽医》 2006. 11:16-8. 

31高雨蔚张宇邢舰誉王屹博丁超薛冰华吕嘉伟史久慧刘忠华糖浓度对三维培养体系下小鼠胚胎干细胞成骨分化的影响口腔医学研究 2015. 31(8):759-62. 

32、徐冉张宇邢舰誉王屹博丁超吕嘉伟伟人悦史久慧刘忠华. BMP7对三维条件下小鼠iPS细胞成骨能力的影响口腔医学研究 2016. 32 (4):322-25. 

33、马婧张宇王健宇薛冰华伟人悦李妍刘忠华猪原始生殖细胞生物学特性的研究《中国细胞生物学学报》 2014. 36(8):1068-75. 

34、邢舰誉张宇陈墨王屹博丁超史久慧刘忠华糖浓度及BMP4对小鼠诱导型多能干细胞成骨作用的研究《中国细胞生物学学报》 2014. 36(5):586-94. 

35、伟人悦,厉雪纯,李妍,于扬,张宇,刘忠华无血清单层细胞诱导法培养猪诱导多能性干细胞定向分化为血管内皮细胞《中国组织工程研究》2020. 24(31):4971-8. 

36、《医学动物试验技术》(ISBN9787117220514 人民卫生出版社  20166月出版

37、张宇,路明,武捷,常珂玮,李海,张宇教育信息化背景下基础医学教学中问题导向思维培养的实践与思考.《高校医学教学研究》2023. 13(6):3-7.