学院：生命科学与技术学院

系所/中心：生物医学信息与基因组学中心

邮箱：zhangyan11@xjtu.edu.cn

地址：陕西省西安市西安交通大学创新港校区18号楼

相分离及复杂疾病易感变异机制研究

主持国家自然科学基金青年项目、陕西省自然科学基金青年项目、中国博士后科学基金面上项目等，还参与多项国家自然科学基金面上项目。

1. Yan Zhang^#, Xin-Hao Li^#, Pai Peng^#, Zi-Han Qiu, Chen-Xi Di, Xiao-Feng Chen, Nai-Ning Wang, Fei Chen, Yin-Wei He, Zhong-Bo Liu, Fan Zhao, Dong-Li Zhu, Shan-Shan Dong, Shou-Ye Hu, Zhi Yang, Yi-Ping Li, Yan Guo*, Tie-Lin Yang*. RUNX2 phase separation mediates long-range regulation between osteoporosis-susceptibility variant and XCR1 to promote osteoblast differentiation. Advanced Science. 2025, 12(6):e2413561. 

2. Yan Zhang^#, Nai-Ning Wang^#, Zi-Han Qiu, Jia-Hao Wang, Wen-Na An, Li-Dan Shi, Fei Chen, Da-Jin Zhang, Si-Yue Wang, Tie-Lin Yang, Shou-Ye Hu*, Yan Guo*. The function of GPCRs in different bone cells. International Journal of Biological Sciences. 2025, 21(11):4736-4761.

3. Yan Zhang^#, Tao Zuo^#, Abigail McVicar, Huilin Yang, Yi-Ping Li*, Wei Chen*. Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis. Bone Research. 2022, 10(1):63.

4. Yan Zhang, Huiwen Chen, Jinjin Wu, Abigail McVicar, Yilin Chen, Jiacan Su, Yi-Ping Li*, Wei Chen*. Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways. International Journal of Biological Sciences. 2024, 20(6): 1965-1977.

5. Yan Zhang, He Wang, Guochun Zhu, Airong Qian*, Wei Chen*. F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NF-κB signaling pathways. International Journal of Biological Sciences. 2020, 16(9): 1629-1639.

6. Yan Zhang^#, Chong Yin^#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 Overexpression by Transfecting the 21-kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation. Human Gene Therapy. 2018, 29(2): 259-270.

7. Nai-Ning Wang^#, Yan Zhang^#, Feng Jiang^#, Dong-Li Zhu, Chen-Xi Di, Shou-Ye Hu, Xiao-Feng Chen, Li-qiang Zhi, Yu Rong, Xin Ke, Yuan-Yuan Duan, Shan-Shan Don, Tie-Lin Yang, Zhi Yang*, Yan Guo*. Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis. American Journal of Human Genetics. 2023, 110 (4), 625-637. 

8. Fei Chen^#, Yan Zhang^#, Pei Peng, Xiao-Ting Huang, Zi-Han Qiu, Bao-Cheng Liu, Tie-Lin Yang, Bo Yang*, Yan Guo*. Isolation and culture of human primary osteoblasts: Comparing the effects of differences in method details on osteoblast characteristics. Genes & Diseases. 2024, 11(2):546-549. 

9. Dong-Li Zhu^#, Yan Zhang^#, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang*, Yan Guo*. Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1. Non-coding RNA research.2025, 15:18-28.