Dewen Zhang

Ph.D.

Professor

Department of Biophysics, School of Basic Medical Sciences,

Institute of Medical Engineering, Translational Medicine Institute

Xi’an Jiaotong University

Xi’an, China

zhangdewen@xjtu.edu.cn

RESEARCH INTEREST

Light-addressable electrochemical imaging and biosensing 

EDUCATION

College of Chemistry and Molecular Engineering, Peking University, Beijing, China

PhD in Analytical Chemistry

July 2014

College of Chemistry and Molecular Engineering, Peking University, Beijing, China

      Bachelor in Chemistry

July 2009

EMPLOYMENT

School of Basic Medical Sciences,  Xi’an Jiaotong University 

        Professor

        January 2025 - present

School of Basic Medical Sciences,  Xi’an Jiaotong University 

         Associate Professor

        November 2018 - December 2024

School of Engineering and Materials Science, Queen Mary University of London

      Postdoctoral Research Assistant, Research Co-Investigator funded by a grant from Biotechnology and Biological Sciences Research Council (BBSRC) of UK

       July 2017 - July 2018

School of Engineering and Materials Science, Queen Mary University of London

      Marie Curie Fellow, funded by Marie Skłodowska-Curie Actions (MSCA)

      July 2015 - July 2017

AWARD

• Marie Skłodowska-Curie Individual Fellowships (H2020-MSCA-IF-2014-660489)
    Funding source: Commission of the European

July 2015 - July 2017 

  PUBLICATIONS  

1 Yao Meng^#; Yaqiong Wang^#; Sen Wang; Mingrui Jiang; De-Wen Zhang*; Jian Zhuang*; Jian Wang*, Photocurrent Polarity-Switchable Imaging of Single Living Cells by Light-Addressable Electrochemical Sensor. Analytical Chemistry 2024, 96(50): 19988–19995.  

2 Qiaoyu Yang; Jiaming Liao; Luyao Feng; Sen Wang; Zhibin Zhao; Jian Wang*; Yazhong Bu*; Jian Zhuang; De-Wen Zhang*, One-step construction of multiplexed enzymatic biosensors using light-addressable electrochemistry on a single silicon photoelectrode. Biosensors and Bioelectronics 2024, 253, 116194. 

3 Fangming Chen^#, Qian Guo^#, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Jian Wang*, De-Wen Zhang*. Label-Free Imaging of Cell Apoptosis by a Light-Addressable Electrochemical Sensor. Analytical Chemistry 2023, 95(23): 8898-8905. 

4 Jian Wang, Fangming Chen, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Yaqiong Wang, De-Wen Zhang*, Liping Du*. Light-addressable electrochemical immunoassay for multiplexed detection of antigen. Sensors and Actuators B: Chemical 2023, 374: 132821.

5 Fangming Chen, Qiaoyu Yang, MingRui Jiang, Yao Meng, De-Wen Zhang*, Jian Wang*. Visualization of electrochemical reactions on microelectrodes using light-addressable potentiometric sensor imaging. Analytica Chimica Acta 2022, 1224: 340237.

6 Yao Meng, Fangming Chen, Chunsheng Wu, Steffi Krause, Jian Wang*, De-Wen Zhang*. Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications. ACS Sensors 2022, 7(7): 1791-1807.

7 Jian Wang, Fangming Chen, Qin Guo, Yao Meng, Mingrui Jiang, Chunsheng Wu, Jian Zhuang, De-Wen Zhang*. Light-Addressable Square Wave Voltammetry (LASWV) Based on a Field-Effect Structure for Electrochemical Sensing and Imaging. ACS Sensors 2021, 6(4): 1636-1642. 

8 Fangming Chen, Xingchuang Fu, Yao Meng, Mingrui Jiang, Jian Wang*, Ying-Lin Zhou*, De-Wen Zhang*. A novel miniaturized homogeneous label-free electrochemical biosensing platform combining integrated microelectrode and functional nucleic acids. Analytica Chimica Acta 2021, 1158: 338415.  

9 Jian Wang^#, Yulan Tian^#, Fangming Chen, Wei Chen, Liping Du, Zhiyuan He, Chunsheng Wu*, De-Wen Zhang*. Scanning Electrochemical Photometric Sensors for Label-Free Single-Cell Imaging and Quantitative Absorption Analysis. Analytical Chemistry 2020, 92(14): 9739-9744.

10 Jian Wang, Zhao Yang, Wei Chen, Liping Du, Bo Jiao, Steffi Krause, Ping Wang, Qiuping Wei, De-Wen Zhang^*, Chunsheng Wu^*. Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Biosensors and Bioelectronics 2019, 146: 111750.  

11 Jian Wang, Shu Kong, Fangming Chen, Wei Chen, Liping Du, Wen Cai, Liquan Huang, Chunsheng Wu^*, De-Wen Zhang^*. A bioelectronic taste sensor based on bioengineered Escherichia coli cells combined with ITO-constructed electrochemical sensors. Analytica Chimica Acta 2019, 1079: 73-78.  

12 Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-Wen Zhang^*, Steffi Krause^*. Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Analytical Chemistry 2019, 91(9): 5896-5903. 

13 Ying Tu, Norlaily Ahmad, Joe Briscoe, De-Wen Zhang^*, Steffi Krause^*, Light-Addressable Potentiometric Sensors Using ZnO Nanorods as the Sensor Substrate for Bioanalytical Applications. Analytical Chemistry, 2018, 90, 8708-8715.

14 De-Wen Zhang, Nikolaos Papaioannou, Naomi Michelle David, Hui Luo, Hui Gao, Liviu Cristian Tanase, Thibault Degousée, Paolo Samorì, Andrei Sapelkin, Oliver Fenwick, Maria-Magdalena Titirici^*, Steffi Krause^*, Photoelectrochemical Response of Carbon Dots (Cds) Derived from Chitosan and Their Use in Electrochemical Imaging. Materials Horizons 2018, 5, 423-428.

15 De-Wen Zhang, Fan Wu, Steffi Krause*, LAPS and SPIM Imaging Using Ito-Coated Glass as the Substrate Material. Analytical Chemistry, 2017, 89, 8129-8133.

16  Fan Wu, Inmaculada Campos, De-Wen Zhang*, Steffi Krause*, Biological Imaging Using Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance Microscopy. Proceedings of the Royal Society. A, Mathematical, physical, and engineering sciences, 2017, 473, 20170130.

17 De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause*, Image Detection of Yeast Saccharomyces Cerevisiae by Light-Addressable Potentiometric Sensors (LAPS). Electrochemistry Communications, 2016, 72, 41-45.

18 Ting Cao, Ji Nie, Liang-Yuan Cai, Xiao-Hui Zhang, De-Wen Zhang*, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Cupric Ion Triggered DNA Diode Based on a Tandem Linkage-Cleavage Reaction. Chemical Communications, 2016, 52, 12490-12493.

19 De-Wen Zhang, Ji Nie, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, Novel Homogeneous Label-Free Electrochemical Aptasensor Based on Functional DNA Hairpin for Target Detection. Analytical Chemistry, 2013, 85, 9378-9382.

20 De-Wen Zhang, Jing-Xin Liu, Ji Nie, Ying-Lin Zhou*, Xin-Xiang Zhang*, Micropipet Tip-Based Miniaturized Electrochemical Device Combined with Ultramicroelectrode and Its Application in Immobilization-Free Enzyme Biosensor. Analytical Chemistry, 2013, 85, 2032-2036.

21 De-Wen Zhang, Cui-Jin Sun, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, An Electrochemical Aptasensor Based on Enzyme Linked Aptamer Assay. Biosensors and Bioelectronics, 2012, 31, 363-368. 

22 De-Wen Zhang, Fang-Ting Zhang, Yi-Ran Cui, Qin-Pei Deng, Steffi Krause, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Label-Free Aptasensor for the Sensitive and Specific Detection of Cocaine Using Supramolecular Aptamer Fragments/Target Complex by Electrochemical Impedance Spectroscopy. Talanta, 2012, 92, 65-71.