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Microfabricating high-aspect-ration structures in polyurethanse-methacrylate(PUMA) disposable microfluidic devices

  • Release Time:2025-04-30
  • Hits:
  • Date: 

    2025-04-30
  • Title of Paper: 

    Microfabricating high-aspect-ration structures in polyurethanse-methacrylate(PUMA) disposable microfluidic devices
  • Journal: 

    Lab on A Chip
  • Summary: 

    We recently reported a new UV-curable polyurethane-methacrylate (PUMA) resin that has excellent qualities as a disposable microfluidic substrate for clinical diagnostic applications. This article discusses strategies to improve the production yield of PUMA chips that contain dense and high-aspect-ratio features, which presents unique challenges in demolding and bonding steps. These fabrication improvements were deployed to produce a microfiltration device that contained closely spaced and high-aspect-ratio columns, suitable for retaining and concentrating cells or beads from a highly diluted suspension.
  • Co-author: 

    Jason S Kuo, Yongxi Zhao, et al.
  • Translation or Not: 

    No
  • Date of Publication: 

    2009-03-26