主要研究领域及方向：

       1.血管药理学；新药评价

      2.中药组分与作用靶点；

      3.环境疾病与受体研究

资历

1988年评为讲师

1995年评为副教授

1997年硕士生导师

1999年获执业药师证书

2004年月评为教授

2005年12月博士生导师

学历

1978.2～1983.1   

西安医学院医疗系  获医学学士学位；

1983.2～1985.12  

西安医科大学药学系  获医学硕士学位；

1991.1～1992.7   

卫生部西医大外语中心学英语；

2001.9～2004.11

西安交通大学生命科学与技术学院 理学博士学位

1.       Cao L , Cao YX , Xu CB, Edvinsson L. Altered endothelin receptor expression and affinity in spontaneously hypertensive rat cerebral          and coronary arteries. PLoS ONE ,2013;8(9):e73761. doi:10.1371/journal.pone.0073761［SCI］

2.        Li J, Cao L , Xu CB, Wang JJ, Cao YX. Minimally modified LDL upregulates endothelin type A receptors in rat coronary arterial smooth muscle cells. Mediators of Inflammation, 2013, doi:10.1155/2013/656570 IF 3.882［SCI］

3.        Zhang JY, Cao YX, Weng WL, Li YK, Zhao L.Paeonol induces vasodilatation in rat mesenteric artery via inhibiting extracellular Ca²⁺ influx and intracellular Ca²⁺ release. Chinese Journal of Integrative Medicine, 2013, 19(7): 510-6［SCI］

4.        Huang LH, Zhang PA, He JY, Liu J, Cao YX. DMSO-soluble cigarette smoke particles alter the expression of endothelin B receptor in rat coronary artery. J Vasc Res 2013;50:238-248 IF 2.434［SCI］

5.        Zhang LX, Chen XL, Yang PB, Zhang SQ, Cao YX . Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx. Pharmacological Reports ,2013, 65:69-79 IF 1.965［SCI］

6.        Sun T, Wang J, Huang LH, Cao YX. Antihypertensive effect of formononetin through regulating the expressionsof eNOS,-HT 2A /1B receptorsand a1-adrenoceptorsinspontaneously rat arteries. European Journal of Pharmacology ,2013,699:241–249 IF 2.592［SCI］

7.        Cao L , Zhang Y, Cao YX , Edvinsson L, Xu CB. Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS ONE,2012;7(3):e33008. IF 4.092［SCI］

8.        Cao L , Zhang Y, Cao YX , Edvinsson L, Xu CB. Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors. PLoS One ,2012;7 ,e44170. IF 4.092［SCI］

9.        Cao L , Xu CB, Zhang Y, Cao YX , Edvinsson L. Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5-HT(1) (B) receptors via the Raf/ERK/MAPK pathway in rats. Acta Physiol (Oxf) ,2013; 207, 183-93.IF 4.4382［SCI］

10.    Li, J, Cao YX , Liu Y. Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. Microvasc Res, 2012;83 (2): 178-84. IF 2.828［SCI］

11.    Li J, Cao YX , Yuan ZY, Cu CB. Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-kappaB pathways. Biochim Biophys Acta, 2012;1821:582-9 IF 5.269［SCI］

12.  Guo ZJ, Zhou K, Cao YX , Li Y, Zhang SQ. Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues. Med Chem Res,2012;21:1647–1651.IF 1.271［SCI］

13.    Sun T, Wang, J, Huang LH, Cao YX. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT( 2A /1B) receptors and alpha(1)-adrenoceptors in spontaneously hypertensive rat arteries. Eur J Pharmacol,2012; IF 2.592［SCI］

14.    Xu WQ, Xiong ZZ, Chen TT, Gao XY, Yu H, Zhang SQ, Cao YX. Vasodilation effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one. Arch Pharm Res,2012;35, 1471-1477. IF 1.538［SCI］

15.    Zhang LX, Zhang SQ, Cao YX. Vasodilation and hypotension of CZ454, an analogue of lacidipine through inhibiting extracellular calcium influx. Arzneimittelforschung ,2012;62, 439-445.［SCI］

16.    Cao L , Xu CB, Zhang Y, Cao YX , Edvinsson L. Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ET_A receptor. BMC Neuroscience,2011;12:109［SCI］

17.    SUN T, LIU R, Cao YX . Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms. Acta Pharmacologica Sinica,2011;32: 1009–1018［SCI］

18.    Cai Y, Cao YX, Lu SM, Xu CB, Cardell LO. Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats. Int Immunol, 2011;23 (7):443-51［SCI］

19.    Zhou K, Wang XM, Zhao YZ, Cao YX , Fu Q, Zhang SQ. Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues. Med Chem Res. 2011.20:1325–1330［SCI］

20.    Long LH, Cao YX , Ma Z, Liu J. Anticoagulant, anti-aggregation and antithrombotic actions of a novel hexapeptide. The Journal of pharmacy and pharmacology, 2011; 63［SCI］

21.    Liu SQ, Li ZL, Cao YX. Autologous late-outgrowth endothelial cells transfusion reduces arterial neointima formation after injury. Cardiovasc Res,2011;90, 171–181［SCI］

22.    Lei Y, Cao YX, Zhang Y, Edvinsson L, Xu CB. Enhanced airway smooth muscle cell thromboxane receptor signaling via activation of JNK MAPK and extracellular calcium influx. Eur J Pharmacol ,2011;650(2-3): 629-638［SCI］ 

23.    Huang LH, He JY, Yuan BX, Cao YX. Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery. Toxicology Letters, 2010;197:243–255［SCI］

24.    Li J, Cao YX , Chen KL, Cao L , Ma Z. Regional variations of vasomotor mediated by G-protein coupled receptors following heat stress in rats. Journal of Pharmacy and Pharmacology, 2010;62: 315–322［SCI］

25.    Lei Y, Cao YX , Zhang YP, Edvinsson L. Activation of JNK results in airway contractile hyperresponsiveness to thromboxane receptor agonist. European Journal of Pharmacology, 2010;634:149–161［SCI］

26.    Fan LH, Tian HY, Wang J, Huo JH, Hu Z, Ma AQ, Cao YX . Downregulation of Kir6.1/SUR2B channels in the obese rat aorta. Nutrition ,2009;25:359-363［SCI］

27.    Fan LH, Tian HY, Yang ML, Ma AQ, Hu Z, Bai XJ, Cao YX . High-fat diet may impair K(ATP) channels in vascular smooth muscle cells. Biomedecine & pharmacotherapy, 2009;63:165-170［SCI］

28.    Long LH, Zhang YT, Wang XF, Cao YX. Montmorillonite adsorbs urea and accelerates urea excretion from the intestine. Applied Clay Science, 2009;46(1): 57-62［SCI］

29.    Liu H, Bai XB, Shi S, Cao YX. Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. The Journal of pharmacy and pharmacology, 2009;61:207-212［SCI］

30.    Long JW, Yang XD, Cao L , Lu SM, Cao YX. Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats. Acta pharmacologica Sinica,2009;30:965-972［SCI］

31.    Ma Z, Long LH, Liu J, Cao YX. Montmorillonite adsorbs uric acid and increases the excretion of uric acid from the intestinal tract in mice. Journal of Pharmacy and Pharmacology,2009;61:1499-504［SCI］

32.    Shahzad M, Yang X, Raza Asim MB, Sun Q, Han Y, Zhang F, Cao YX , Lu SM. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulmonary pharmacology & therapeutics, 2009;22:37-43［SCI］

33.    Zhang JY, Cao L , Zheng XH, Xu CB, Cao YX. Dimethylsulfoxide-soluble smoking particles and nicotine affect vascular contractibility. Arch Pharm Res, 2009;32:1479-1485［SCI］

34.    Zhang YT , Wang XF, Long LH, Liu T, Cao YX. Montmorillonite adsorbs creatinine and accelerates creatinine excretion from the intestine. The Journal of pharmacy and pharmacology,2009;61: 459-464［SCI］

35.    Yang L, Qi GY, Cao YX , Liu J, Zhao M. The relationship between endothelin receptors and chronic venous insufficiency of lower extremities. Zhonghua Wai Ke Za Zhi,2008; 46:1325-8［SCI］

36.    Long LH, Ma Z, Cao YX , Liu J, Zhai T. Effect of Montmorillonite on Diffusion of Creatinine Between Blood Vessel and Intestine. Bioinformatics and Biomedical Engineering 2008;1237-40［SCI］

37.    Li JT, Zhang YL, Ma JQ, Gao J, Wang CS, Liu J, Cao YX. Montmorillonite absorbs uric acid and decreases the concentration of uric acid in the serum. Bioinformatics and Biomedical Engineering,2008;Shanghai, China［SCI］

38.    Li J, Cao YX , Cao L , Liu Y. Heat stress alters G-protein coupled receptor-mediated function and endothelium-dependent relaxation in rat mesenteric artery. Eur J Pharmacol ,2008; 588: 280-5［SCI］

39.    Lei Y, Cao YX , Xu CB, Zhang Y. The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res,2008;9:71 ［SCI］

40.    Li J, Cao YX, Liu J, Liu Y, Xu CB. Altered G-protein coupled receptor-mediated vasoactivity and endothelium-dependent vasodilation in heat stress rats. Basic & Clinical Pharmacology & Toxicology, 2008;102: 54-54.Suppl. 1  Published: 309Y;IF 1.821［SCI］

41.    Cao YX, Zhang JY, Liu j, Xu CB. High concentration nicotine enhances endothelin type A and type B receptor-mediated contractions in rat mesenteric artery. Basic & Clinical Pharmacology & Toxicology,2008;102:54-54, Suppl 1 309Y; IF 1.821［SCI］

42.    Zhang W, Cao YX , He JY, Xu CB. Down-regulation of α1-adrenoceptor expression by lipid-soluble smoke particles through transcriptional factor nuclear factor-κB pathway. Basic & Clinical Pharmacology & Toxicology,2007;101:401–406 [SCI]

43.    He JY, Zhang W, He LC, Cao YX. Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca²⁺ influx and release. European Journal of Pharmacology ,2007;573:170–175 [SCI]

44.    Li J, Cao YX , Liu H, Xu CB. Enhanced G-protein coupled receptors-mediated contraction and reduced endothelium-dependent relaxation in hypertension. Eur J Pharmacol, 2007;557:186-194 [SCI]

45.    Cao YX , Yang XJ, He JY, Liu J, Li KX. Hypotensive and vasodilator effects of S-D. Basic & Clinical Pharmacology & Toxicology,2006;99 (6):425-30 [SCI]

46.    Cao YX , Zhang W, He JY, He LC, Xu CB . Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca²⁺ influx and release .Vascular Pharmacology,2006;45:171–176 [SCI]

47.    Cai Y, Meng XF, Cao YX , Lu H, Zhu SF, Zhou LZ. Montmorillonite ameliorates hyperthyroidism of rats and mice attributed to its adsorptive effect. European Journal of Pharmacology,2006;551(1-3):156-161［SCI］

48.    Luo HL, Zang WJ, L J, Yu XJ, Lin YX, Cao YX. The Protective Effect of Captopril on Nicotine-Induced Endothelial Dysfunction in Rat. Basic & Clinical Pharmacology & Toxicology ,2006; 99: 237-245 [SCI]

49.    Luo GG, Cao YX , Edvinsson L, Xu CB. Vascular endothelin ETB receptor-mediated contraction requires phosphory- lation of ERK1/2 proteins. European Journal of Pharmacology,2006; 538:124-131［SCI］

50.    Cao YX, Xu CB, Luo GG, Edvinsson L. Up-regulation of alpha1A- adrenoceptors in rat mesenteric artery involves intracellular signal pathways. Basic & Clinical Pharmacology & Toxicology ,2006; 98(1):61-67［SCI］

51.    Zhang JY, Cao YX, Xu CB, Edvinsson L. Lipid-soluble smoke particles damage endothelial cells and reduce endothelium-dependent dilatation in rat and man. BMC Cardiovascular Disorders, 2006;6:3［SCI］

52.    Cao YX, Zheng JP, He JY, Li J,Xu CB, Edvinsson L. Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca2+-influx and Ca2+-release. 28 2005;28(6):709-715［SCI］

53.    Cao YX, He LC,Xu CB, Luo GG, Edvinsson L. Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery.Basic & Clinical Pharmacology & Toxicology, 2005;96(4): 282-288［SCI］

54.    Luo GG, Xu CB, Cao YX, Edvinsson L. Transcriptional up-regulation in expression of 5-hydroxytryptamine2A and transcriptional down-regulation of angiotensin II type 1 receptors during organ culture of rat mesenteric artery. Basic & Clinical Pharmacology & Toxicology ,2004;95(6):280-7［SCI］ 

55.    Cao YX , He LC, XU CB, Edvinsson L. Alteration in contractile response to noradrenaline, 5-hydroxytryptamine, sarafotoxin 6c , and angiotensin Ⅱ in rat mesenteric artery during organ culture. Academic Journal of Xian Jiangtong University, 2004;16(2):156-160［SCI］

56.  Cao YX, Che XP. Effects of manganese on neuro-muscuiar junction  transmission. J Xian Med Univ,l994;6(1)［SCI］