The dynamic behavior of spiral waves in stochastic Hodgkin Huxley neuronal networks with ion channel blocks
发布时间：2025-04-30
点击次数：
- 发布时间：
- 2025-04-30
- 论文名称：
- The dynamic behavior of spiral waves in stochastic Hodgkin Huxley neuronal networks with ion channel blocks
- 发表刊物：
- Nonlinear Dynamics
- 摘要：
- Chemical blocking is known to affect neural network activity. Here, we quantitatively investigate the dynamic behavior of spiral waves in stochastic Hodgkin–Huxley neuronal networks during sodiumor potassium-ion channel blockages.When the sodiumion channels are blocked, the spiral waves first become sparse and then break. The critical factor for the transition of spiral waves (xNa) is sensitive to the channel noise. However, with the potassium-ion channel block, the spiral waves first become intensive and then form other dynamic patterns. The critical factor for the transition of spiral waves (xK) is insensitive to the channel noise. With the sodium-ion channel block, the spike frequency of a single neuron in the network is reduced, and the collective excitability of the neuronal network weakens. By blocking the potassium ion channels, the spike frequency of a single neuron in the network increases, and the collective excitability of the neuronal network is enhanced. Lastly, we found that the behavior of spiral waves is directly related to the system synchronization. This research will enhance our understanding of the evolution of spiral waves through toxins or drugs and will be helpful to find potential applications for controlling spiral waves in real neural systems
- 合写作者：
- Shao-Bao Liu, Ying Wu,. Jia-Jia Li, Yong Xie, Ning Tan
- 卷号：
- 73
- 页面范围：
- 1055-1063
- 是否译文：
- 否
- 发表时间：
- 2013-04-03