A neglected GABAergic astrocyte: Calcium dynamics and involvement in seizure activity
发布时间：2025-04-30
点击次数：
- 发布时间：
- 2025-04-30
- 论文名称：
- A neglected GABAergic astrocyte: Calcium dynamics and involvement in seizure activity
- 发表刊物：
- SCIENCE CHINA Technological Sciences
- 摘要：
- Gamma-aminobutyric acid (GABA) contributes substantially to neurocognitive function as an important inhibitory
neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy are not well
understood, since GABA agonists are not quite effective in treating epilepsy. Knowledge of the mechanism of action of GABA would contribute to review previously proposed anti-epileptic processes by GABA agonists. In this study based on recent experiments on GABAergic astrocytes, we developed a modified GABAergic astrocyte model, and successfully simulated a long-lasting Ca2+oscillation in astrocytes after 0.5-s stimulation of GABAergic transmission. We then incorporated this GABAergic astrocyte model into a classical Ullah-Schiff seizure model and surprisingly found that this GABAergic astrocyte model functions to hinder the anti-epileptic action of GABA agonists, thereby explaining their low efficiency in previous experiments. These results also update our knowledge of the mechanism of action of GABA and the effects of astrocytes on physiological and pathological functions of the brain.
- 合写作者：
- LI JiaJia, XIE Yong, YU YuGuo, DU MengMeng, WANG Rong and WU Ying
- 卷号：
- 60(7)
- 页面范围：
- 1003-1010
- 是否译文：
- 否
- 发表时间：
- 2017-02-14