主要科研情况：

近五年发表的一作和通讯作者的文章

1. Zhang K#, Li S#, Wang Y#, Wang Z, Mulvenna N, Yang H, Zhang P, Chen H, Li Y, Wang H, Gao Y, Wigneshweraraj S, Matthews S, Zhang K, Liu B. Bacteriophage protein peip is a potent bacillus subtilis enolase inhibitor. Cell Rep 2022;40:111026. (IF: 9.995)
2. Li Y, Zhu F, Li Y, Pan S, Wang H, Yang Z, Wang Z, Hu Z, Yu J, Barritt JD, Li T, Liu X, Wang Y*, Ma X*, Liu B*. Bacteriophages allow selective depletion of gut bacteria to produce a targeted-bacterium-depleted mouse model. Cell Reports Methods 2022:100324.
3. Guo R, Gao J, Hui L, Li Y, Liu J, Fu Y, Shi L, Wang Y*, Liu B*. An improved method for quick quantification of unsaturated transferrin. Biosensors (Basel) 2022;12. (IF: 5.743)
4. Shi X, Hu Z, Gan B, He Y, Zhang L, Chen M, Wang Y*, Li X*. Multivariate evaluation of DNA quality differences in different preanalytical procedures in mouse livers. Biopreserv Biobank 2022. (IF：2.256)
5. Peipei Zhang^#, Xiaohui Zhao^#, Yawen Wang^#, Ke Du, Zhihao Wang, Jianfeng Yu, Gang Chang, Steve Matthews , Hongliang Wang* , Bing Liu*.(2022). Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins. Proc Natl Acad Sci U S A. 119(9):e2116278119.
6. Bing Liu ^#*,, Shanshan Li ^#, Yang Liu ^#, Huan Chen,  Zhenyue Hu,  Zhihao Wang,  Yimin Zhao, Lei Zhang,  Biyun Ma,  Hongliang Wang,  Steve Matthews,  Yawen Wang*,, Kaiming Zhang*,. Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Research, 2021 Oct 6;gkab875. 
7. Li J. ^#, Gao J.,^# Li N., Wang,Y.* (2021). Distribution of human papillomavirus genotypes in western China and their association with cervical cancer and precancerous lesions. Archives of Virology, 166:853–862.
8. Wang, F., Wang, X., Li, N., Liu, J., Zhang, L., Hui, L., Feng, A., Wang, Z., & Wang, Y.* (2021). Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment. Cancer science, 112(1), 133–143. 
9. Zhang, K., Wang, Z., Chang, G., Wang, H., Wang, Y.*, & Liu, B*. (2020). Resonance assignments of bacteriophage T4 Y04L protein. Biomolecular NMR assignments, 14(1), 51–54. （IF：0.765）
10. Hu, Y., Chen, T., Liu, M., Zhang, L., Wang, F., Zhao, S., Liu, H., Xia, H., Wang, Y.*, & Li, L*. (2020). Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta ophthalmologica, 98(8), 859–863.
11. Zhao, S., Zhang, K., Jiang, S., Liu,Zhi., Wang Zhi., Wang, Y.*, & Liu, B*. (2019). Resonance assignments of sigma factor S binding protein Crl from Escherichia coli.. Biomolecular NMR assignments, 13(1), 223-226.
12. Li, Y., Liu, Z., Hui, L., Liu, X., Feng, A., Wang, W., Zhang, L., Li, N., Zhou, G., Wang, Q., Han, Q., Lv, Y., Wang, Q., Yang, G., & Wang, Y. * (2017). Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus. British journal of pharmacology, 174(14), 2261–2272.

近五年参与发表的文章：

1. Kaining Zhang, Shanshan Li, Yawen Wang, Zhihao Wang, Nancy Mulvenna, Hang Yang, Peipei Zhang, Huan Chen, Yan Li, Hongliang Wang , Yongxiang Gao, Sivaramesh Wigneshweraraj, Steve Matthews, Kaiming Zhang, Bing Liu. (2022).Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep. 5;40(1):111026.
2. Wang, Z., Zhao, S., Li, Y., Zhang, K., Mo, F., Zhang, J., Hou, Y., He, L., Liu, Z., Wang, Y., Xu, Y., Wang, H., Buck, M., Matthews, S. J., & Liu, B. (2021). RssB-mediated σ^S Activation is Regulated by a Two-Tier Mechanism via Phosphorylation and Adaptor Protein - IraD. Journal of molecular biology, 433(3), 166757.
3. Ren, Y., Liu, W., Zhang, L., Zhang, J., Bi, J., Wang, T., Wang, M., Du, Z., Wang, Y., Zhang, L., Wu, Z., Lv, Y., Meng, L., & Wu, R. (2021). Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis. Clinical and translational medicine, 11(2), e295.
4. Zhang, D., Guo, R., Lei, L., Liu, H., Wang, Y., Wang, Y., Qian, H., Dai, T., Zhang, T., Lai, Y., Wang, J., Liu, Z., Chen, T., He, A., O'Dwyer, M., & Hu, J. (2021). Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. Journal of leukocyte biology, 109(1), 13–22.
5. Li, Y., Li, G., Wang, Z., Chen, W., Wang, H., Wang, Y., & Liu, B. (2021). Resonance assignments of the cytoplasmic domain of ECF sigma factor W pathway protein YsdB from Bacillus subtilis. Biomolecular NMR assignments, 15(1), 103–106.
6. Yang, Y., Ke, Z., Wang, Z., Li, Y., Li, Y., Wang, Y., & Liu, B. (2020). ¹H, ¹³C and ¹⁵ N NMR assignments of solubility tag protein Msyb of Escherichia coli. Biomolecular NMR assignments, 14(2), 251–254.
7. Wei, S., Bi, J., Yang, L., Zhang, J., Wan, Y., Chen, X., Wang, Y., Wu, Z., Lv, Y., & Wu, R. (2020). Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clinical and translational medicine, 10(5), e173.
8. Bi, J., Zhang, J., Ren, Y., Du, Z., Zhang, Y., Liu, C., Wang, Y., Zhang, L., Shi, Z., Wu, Z., Lv, Y., & Wu, R. (2020). Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases. JCI insight, 5(13), e136277.
9. Wang, Z., Liang, Y., Liu, H., Wang, Y., Wang, H., & Liu, B. (2020). Resonance assignments of bacteriophage SPO1 Gp49 protein. Biomolecular NMR assignments, 14(1), 111–114.
10. Zhang, J., Ke, M., Ren, Y., Bi, J., Du, Z., Zhang, M., Wang, Y., Zhang, L., Wu, Z., Lv, Y., & Wu, R. (2019). Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease markers, 2019, 9850191.
11. Wang, Z., Zhao, S., Jiang, S., Wang, Y., Buck, M., Matthews, S., & Liu, B. (2019). Resonance assignments of N-terminal receiver domain of sigma factor S regulator RssB from Escherichia coli. Biomolecular NMR assignments, 13(2), 333–337.
12. Zhang, P., Wang, Z., Zhao, S., Wang, Y., Matthews, S., & Liu, B. (2019). ¹H, ¹³C and ¹⁵N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46. Biomolecular NMR assignments, 13(1), 245–247.
13. Liu, B., Wang, Z., Lan, L., Yang, Q., Zhang, P., Shi, L., Lang, Y., Tabib-Salazar, A., Wigneshweraraj, S., Zhang, J., Wang, Y., Tang, Y., Matthews, S., & Zhang, X. (2018). A Rapid Colorimetric Method to Visualize Protein Interactions. Chemistry (Weinheim an der Bergstrasse, Germany), 24(26), 6727–6731.
14. Wang, W., Li, Y., Wang, Y., Ren, S., Li, Y., & Wang, B. (2018). Polyactin A is a novel and potent immunological adjuvant for peptide-based cancer vaccine. International immunopharmacology, 54, 95–102.
15. Wang, X., Li, Y., Chen, W., Wang, Y., Hui, L., Liu, J., Li, N., Zhang, L., Zou, Y., & Wang, F. (2017). Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance. Experimental cell research, 353(2), 72–78.
16. Sun, Y., Mo, L., Feng, X., Yang, D., Tan, T., Zeng, L., Hui, L., Wang, Y., Liu, C., & He, L. (2017). Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population. Pharmacogenomics, 18(3), 255–264.

主持或参加科研项目

[1] 国家自然科学基金青年基金项目《融合蛋白质转导域的抗HBV核心蛋白穿膜抗体细胞内靶向抗病毒作用研究》，主持．（22万元）

[2] 生物安全关键技术研发重点专项《中国人类遗传资源样本库建设》子课题1项负责人。（65万元）

[3] 陕西省科技攻关项目，《同型半胱氨酸酶联免疫检测试剂盒的研制》，主持。（3万元）

[4] 国家“重大新药创制”科技重大专项，《GoldMag金磁微粒标记CYP2C19基因分型试纸条开发及其在硫酸氯吡格雷个体化临床用药中的应用》（356.97万元），参与。

[5] 国家“863”计划课题《脑血栓治疗新方法——多态脂质纳米微泡》（319万元），参与。

[6] 陕西省科技统筹创新工程计划项目《α-甘露聚糖肽佐剂的乳腺癌治疗性疫苗关键技术的研究》（50万元），参与。

[7] 国家自然科学基金面上项目《以JC病毒VLP为载体探讨中枢神经系统定向基因传递》，参与。

[8] 国家自然科学基金面上项目《HCV核心蛋白对肝脏干细胞的转分化作用研究》，参与。

[9] 国家自然科学基金面上项目《MRI、磁共振波谱及多种生物学指标在Alzheimer病早期诊断中联合应用的研究》，参与。

[10] 国家自然科学基金面上项目《贫困山区巨细胞病毒UL97和UL54基因突变与宫内感染的关系研究》，参与。

奖励

[1]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》，陕西省人民政府，陕西省科学技术进步奖，三等奖，2012年．

[2]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》，西安市人民政府，西安市科学技术进步奖，二等奖，2011年．

专利

[1] 专利名称：一种鸭乙型肝炎病毒的荧光定量PCR检测方法及试剂．发明专利号：201310046253.8（第一发明人）

[2] 专利名称：一种靶向病毒核心蛋白的穿膜抗体及其制备方法．专利受理号：201310418409.0（第一发明人）

[3] 专利名称：血栓诊断和或治疗用含气干粉活性剂及其制备工艺．发明专利号：2005100442767.1（第五发明人）