发布时间：2025-04-30

论文名称：Recent advances in screening active components from natural products based on bioaffinity techniques

发表刊物：Acta Pharmaceutica Sinica B

摘要：Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.

合写作者：Xiaofang Hou, Meng Sun, Tao Bao, Xiaoyu Xie, Fen Wei, Sicen Wang*

卷号：2020, 10

页面范围：1800-1813

是否译文：否

发表时间：2020-10-22