发布时间：2025-04-30

论文名称：Engineering biomimetic graphene nanodecoys camouflaged with the EGFR/HEK293 cell membrane for targeted capture of drug leads

发表刊物：Biomaterials Science

摘要：Advanced graphene (G)-based nanomaterials have risen as emerging stars for biomedical applications
over the past decade due to their unique physicochemical properties. However, the preparation of
G-based nanomaterials with satisfactory bioactivity to meet the growing demands of multitasking applications in biocomplexity systems remains a challenge. Herein, we presented a biomimetic route to modify
graphene oxide (GO) using high expression epidermal growth factor receptor cell membrane (CM).
Owing to the inherent properties of the CM for multifaceted interaction with active ligands, the well
camouflaged GO could capture the drug leads with targeting properties. The as-prepared CM-coated
magnetic GO exhibited excellent binding properties, including good selectivity, high adsorption capacity,
and suitable adsorption rates. In addition, by coupling this assay with mass spectrometry, two potential
bioactive compounds, luteolin and caffeic acid, were screened from Taraxacum mongolicum Hand.-
Mazz. It is anticipated that this biomimetic approach can open new possibilities for the rational design of
improved G-based biocomposites and extend their bioapplications.

合写作者：Q Hu, XL Zhang, LL Jia, XY Zhen, XY Pan, XY Xie*, SC Wang*

卷号：8

页面范围：5690

是否译文：否

发表时间：2020-10-06