- Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, Wang B, Su A, Tian H, Li Y, Liang G, Wang C, Shyy J, Xiong Y, Chen F, Yuan JX, Liu J, Zhou B, Wettschureck N, Offermanns S, Yan Y, Yuan Z, Wang S. PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. J Clin Invest. 2025.
- Xu L, Yang C, Pang K, Zhang Y, He Y, Liu S, Tian H, Shao Z, Wang S, Liu X, Li T, Cao Y, Yan L, Liu J, Wang Y, Li Y, Zhao W, Wang Y, Yan Y, Wang S. Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity. Mol Metab. 2025.
- Chen X, Shao J, Brandenburger I, Qian W, Hahnefeld L, Bonnavion R, Cho H, Wang S, Hidalgo J, Wettschureck N, Geisslinger G, Gurke R, Wang Z, Offermanns S. FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. Nat Commun. 2025.
- Cho H, Lai CC, Bonnavion R, Alnouri MW, Wang S, Roquid KA, Kawase H, Campos D, Chen M, Weinstein LS, Martínez A, Looso M, Sanda M, Offermanns S. Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science. 2025.
- Jin YJ, Liang G, Li R, Wang S, Alnouri MW, Bentsen M, Kuenne C, Günther S, Yan Y, Li Y, Wettschureck N, Offermanns S. Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. Nat Cardiovasc Res. 2025.
- Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. Proc Natl Acad Sci U S A. 2024.
- Liang G, Wang S, Shao J, Jin YJ, Xu L, Yan Y, Günther S, Wang L, Offermanns S. Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Circ Res. 2022.
- Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 2022.
- Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021.
- Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021.
- Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2021.
- Xu L, Wettschureck N, Bai Y, Yuan Z, Wang S. Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. J Hepatol. 2021.
- Wang L, Wang S, Shi Y, Li R, Günther S, Ong YT, Potente M, Yuan Z, Liu E, Offermanns S. YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 2020.
- Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 2020.
- Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019.
- Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP. The polarity protein Scrib limits atherosclerosis development in mice. Cardiovasc Res. 2019.
- Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR. Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019.
- Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018.
- Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018.
- Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016.
- Kwon HB, Wang S, Helker CS, Rasouli SJ, Maischein HM, Offermanns S, Herzog W, Stainier DY. In vivo modulation of endothelial polarization by Apelin receptor signalling. Nat Commun. 2016.
- Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S. Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling. Cardiovasc Res. 2016.
- Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015.
- Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015.
- Althoff TF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S. Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med. 2012.