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课题组情况：课题组成立于2013年，聚焦于基于活性小分子或元素构建高性能生物活性材料，研究其生物活性效应，发展新型医疗器械技术，实现在骨骼肌肉组织修复、糖尿病创面修复、肿瘤切除组织修复与治疗、耐药菌感染组织修复、口服及透皮纳米制剂等医学领域应用。
代表性学术论文：
【31】J. Ma, S. Li, L. Zhang*, B. Lei*.Oxidativestress-scavenging thermo-activated MXene hydrogel for rapid repair of MRSA impaired wounds and burn wounds. Mater. Today, 2024, 80, 139 (IF 21.0).
【30】X. Wang, L. Zhang, Y. Zhao, Z.Qin, B. Hu, L. Zhang, Y. Jiang, Q. Wang, Z. Liang, X. Tang, J. Wu, F. Cao, L. Bu, B Lei*, G. Lu*. Electro‐Optically Configurable Synaptic Transistors With Cluster‐Induced Photoactive Dielectric Layer for Visual Simulation and Biomotor Stimuli. Adv. Mater., 2024, 36, 2406977 (IF 26.8).
【29】T.Leng, L. Zhang, J. Ma, X. Qu*, B Lei*.Intrinsically bioactive multifunctional Poly (citrate-curcumin) for rapid lung injury and MRSA infection therapy . Bioact.Mater., 2024, 41, 158 (IF 20).
【28】X. Jiang, J. Ma, ....., C. Lin*, B Lei*, C. Mao*. Highly bioactive MXene-M2-exosome nanocomposites promote angiogenic diabetic wound repair through reconstructing high glucose-derived immune inhibition. ACS Nano, 2024, 18, 4269 (IF 16)
【27】J. Ma, L. Zhang*, B Lei*. Multifunctional MXene-based bioactive materials for integrated regeneration therapy. ACS Nano, 2023, 17, 19526 (IF 16).
【26】X. Jiang, J. Ma, K. Xue, J. Chen, Y. Zhang, G. Zhang, K. Wang, Z. Yao, Q. Hu, C. Lin*, B Lei*, C. Mao*. Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair. Bioact. Mater., 2023, 15, 319 (IF 20).
【25】X Qu, Y. Guo, C. Xie, S. Li, Z. Liu, B Lei*. Photoactivated MXene nanosheets for integrated bone–soft tissue therapy: effect and potential mechanism. ACS Nano, 2023, 17, 7229 (IF 16).
【24】M Chen, D D Winston, M. Wang, W. Niu, W. Cheng, Y. Guo, Y. Wang, M. Luo, C. Xie, T. Leng, X. Qu*, B Lei*. Hierarchically multifunctional bioactive nanoglass for integrated tumor/infection therapy and impaired wound repair. Materials Today, 2022, 53, 27 (IF 31.04).
【23】W. Niu, M. Chen, Y Guo, M Wang, M. Luo, W Cheng, Y. Wang, B. Lei*. A Multifunctional Bioactive Glass-Ceramic Nanodrug for Post-Surgical Infection/Cancer Therapy-Tissue Regeneration. ACS Nano, 2021, 15, 14323 (IF 18.0).
【22】M. Wang, P.Xu*, B. Lei*. Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering. Bioactive Materials, 2023, 19, 511 (IF 16.8).
【21】W. Niu, Y Guo, Y Xue, M Wang, M Chen, D D Winston, W Cheng, B. Lei*. Biodegradable multifunctional bioactive Eu-Gd-Si-Ca glass nanoplatform for integrative imaging-targeted tumor therapy-recurrence inhibition-tissue repair. Nano Today, 2021, 38, 101137 (IF 18.9).
【20】Z. Tu, M. Chen, M Wang, Z Shao, X Jiang, K Wang, Z Yao, S Yang, X Zhang, W Gao, C Lin*, B Lei*, C Mao*. Engineering Bioactive M2 Macrophage‐Polarized Anti‐Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair. Advanced Functional Materials, 2021, 31, 2100924 (IF 19.9).
【19】M. Yu, Y. Du, Y. Han, B. Lei*. Biomimetic Elastomeric Bioactive Siloxane-Based Hybrid Nanofibrous Scaffolds with miRNA Activation: A Joint Physico-Chemical-Biological Strategy for Promoting Bone Regeneration. Advanced Functional Materials, 2020, 30(4), 1906013 (IF 19.9).
【18】Y. Xi, J. Ge, M. Wang, M. Chen, W. Niu, W. Cheng, Y. Xue, C. Lin, B. Lei*. Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing. ACS Nano, 2020, 14(1),2904-2916. (IF 18.0)
【17】Y. Xue, W. Niu, M. Wang, M. Chen, Y. Guo, B. Lei*. Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration. ACS Nano, 2020, 14(1),442-453. (IF 18.0)
【16】L. Zhou, Y. Xi, Y. Xue, M. Wang, Y. Liu, Y. Guo, B. Lei*. Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing. Advanced Functional Materials, 2019, 29(22)1806883 (IF 19.9).
【15】M. Wang, C. Wang, M. Chen, Y. Xi, W. Cheng, C. Mao*, T. Xu, X. Zhang, C. Lin, W. Gao, Y. Guo, B. Lei*. Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release. ACS Nano, 2019, 13(9),10279-10293. (IF 18.0)
【14】J. Yan, S. Yan, P. Hou, W. Lu, P. Ma, W. He*, B. Lei*. A Hierarchical Peptide–Lanthanide Framework To Accurately Redress Intracellular Carcinogenic Protein–Protein Interaction. Nano Letters, 2019, 19(11), 7918-7926. (IF 12.2)
【13】Y. Xi, J. Ge, Y. Guo, B. Lei*, P Ma. Biomimetic elastomeric polypeptide-based nanofibrous matrix for overcoming multidrug-resistant bacteria and enhancing full-thickness wound healing/skin regeneration. ACS Nano, 2018, 12(11),10772-10784. (IF 18.0).
【12】J. Yan, W. He*, S. Yan, F. Niu, T. Liu, B. Ma, Y. Shao, Y. Yan, G. Yang, W. Lu, Y. B. Lei*, P. Ma. Self-assembled peptide–lanthanide nanoclusters for safe tumor therapy: overcoming and utilizing biological barriers to peptide drug delivery. ACS Nano, 2018, 12(2),2017-2026. (IF 18.0).
【11】Y. Du, M. Yu, J. Ge, P.Ma*, X. Chen, B. Lei*.Development of a multifunctional platform based on strong, intrinsically photoluminescent and antimicrobial silica‐poly (citrates)‐based hybrid biodegradable elastomers for bone regeneration. Advanced Functional Materials, 2015, 25(31), 5016-5029. (IF 19.9）.
【10】M. Wu, Y. Xue, N. Li, H. Zhao, B. Lei*, M. Wang, Y. Du*, C. Yan. Tumor‐Microenvironment‐Induced Degradation of Ultrathin Gadolinium Oxide Nanoscrolls for Magnetic‐Resonance‐Imaging‐Monitored, Activatable Cancer Chemotherapy. Angewandte Chemie International Edition, 2019, 58(21), 6880-6885. (IF 16.8).
【9】M. Wang, M. Chen, W. Niu, D.D. Winston, W. Cheng, B. Lei*. Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy. Biomaterials, 2020, 261,12031. (IF15.3).
【8】L. Zhou, H. Zheng, S. Wang, F. Zhou, B Lei*, Q Zhang*. Biodegradable conductive multifunctional branched poly (glycerol-amino acid)-based scaffolds for tumor/infection-impaired skin multimodal therapy. Biomaterials, 2020, 261,120300. (IF15.3).
【7】L. Xu, Y. Xue, J. Xia, X. Qu, B. Lei*, T. Yang, X. Zhang, N. Li, H. Zhao, M. Wang, M. Luo, C. Zhang, Y. Du*, C. Yan. Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics. Biomaterials, 2020, 230,119670. (IF15.3).
【6】M. Wang, Y. Guo, Y. Xue, W. Niu, M. Chen, P. Ma, B. Lei*. Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo. Biomaterials, 2019, 199,10-21. (IF15.3).
【5】Y. Li, N. Li, J. Ge, Y. Xue, W. Niu, M. Chen, Y. Du, P. Ma, Bo Lei*. Biodegradable thermal imaging-tracked ultralong nanowire-reinforced conductive nanocomposites elastomers with intrinsical efficient antibacterial and anticancer activity for enhanced biomedical application potential. Biomaterials, 2019, 201,68-76. (IF 15.3)
【4】Y. Du, J. Ge, Y. Li, P. Ma, B. Lei*. Biomimetic elastomeric, conductive and biodegradable polycitrate-based nanocomposites for guiding myogenic differentiation and skeletal muscle regeneration. Biomaterials, 2018, 157, 40-50. (IF15.3).
【3】J. Ge, K. Liu, W. Niu, M. Chen, M. Wang, Y. Xue, C. Gao, P. Ma, B. Lei*. Gold and gold-silver alloy nanoparticles enhance the myogenic differentiation of myoblasts through p38 MAPK signaling pathway and promote in vivo skeletal muscle regeneration. Biomaterials, 2018, 175,19-29 (IF 15.3).
【2】F. Zhao, B. Lei*, X. Li, Y. Mo, R. Wang, D. Chen*, X. Chen*. Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes. Biomaterials, 2018, 178,36-47 (IF 15.3).
【1】 J. Xia#, Y. Xue#, B. Lei#, L. Xu, M. Sun, N. Li, H. Zhao, M. Wang, M. Luo, C. Zhang, B. Huang*, Y. Du*, C. Yan. Multi-modal channel cancer chemotherapy by 2D functional gadolinium metal-organic framework. National Science Review, 2021, 8, nwaa221. (IF 23.1) (# Co-first author).