刘亚乐

博士，副研究员

博士研究生导师

西安交通大学第二附属医院

皮肤病院

陕西省青年科技新星

2022.1-至今: 西安交通大学第二附属医院，皮肤科，副研究员
2019.3-2021.8: 加州大学旧金山分校，博士后
2017.9-2022.2：西安交通大学第二附属医院，皮肤科，助理研究员

2014.9-2017.9: 西安交通大学医学部, 博士研究生(硕博连读博士阶段) 皮肤性病学 

2012.9-2014.6: 西安交通大学医学部, 硕士研究生(硕博连读硕士阶段) 皮肤性病学 

研究方向：自身免疫性疱病发病机制及治疗

项目主持：国家自然科学基金2项：

①抗BP180抗体活化基底层角质形成细胞中Fn14-TRAF2-ZFP36轴促进大疱性类天疱疮炎症反应的机制，国家自然科学基金面上项目（82373476），2024.01-2027.12；

②TWEAK活化Fn14 ADAM17-EGFR 信号轴促进大疱性类天疱疮水疱形成的分子机制，国家自然科学基金青年项目（81803137），2019.01-2021.12；

省级创新能力支撑计划1项，西安交通大学第二附属医院“育英”计划-精英人选首批入选者（全院4位），其它纵向课题4项（现有在研经费>280万）。

发表SCI文章35篇，其中第一作者或通讯作者21篇。

代表性论文：

1. Ren K, Peng X, Duan X, Feng R, Cook C, Lu M, Li M, Gu H, Wang X, Deng G, Ma H, Liu Y, Xia Y. Synergistic effects of LCN2 and TWEAK on the progression of psoriasis. Cell Mol Immunol. 2025 Jul;22(7):760-775. (共同通讯作者)
2. Ran Y, Peng X, Xia Y, Liu H, Liu Y. Periostin in Bullous Pemphigoid: A Potential Biomarker of Disease Activity and Severity. Exp Dermatol. 2025 Feb;34(2):e70067. (通讯作者)
3. Ran Y, Peng X, Xia Y, Liu Y. IL-24 for bullous pemphigoid severity: A case-control study. J Eur Acad Dermatol Venereol. 2025 Jun;39(6):e511-e513.  (通讯作者)
4. Peng X, Wang S, Wu K, Cook C, Li L, Wang Z, Gu H, Lu M, Hu G, Ren K, Hu G, Zeng W, Xia Y, Liu Y. Effect of opioid receptor antagonist on mitigating tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced apoptolysis in pemphigus pathogenesis. J Autoimmun. 2024 Sep 13;149:103307.  (通讯作者)
5. Liu YL, Ran YT, Zhang YF, Peng XT, Xia YM, Yan HL. Efficacy and safety of dupilumab in the treatment of Kimura's disease. QJM. 2024 Aug 1;117(8):575-580. (第一、通讯作者)
6. Wang S, Li L, Cook C, Zhang Y, Xia Y, Liu Y. A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review. Stem Cell Res Ther. 2022 Jun 21;13(1):270.  (通讯作者)
7. Cook CP, Taylor M, Liu Y, et al. A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity. Cell Rep Med. 2022 Aug 16;3(8):100715. (共一作者)
8. Liu Y, et al. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci Immunol. 2022; 7(70): eabl9165. (第一作者)
9. Liu Y, et al. Defining patient-level molecular heterogeneity in psoriasis vulgaris based on single-cell transcriptomics. Front Immunol. 2022 Jul 26;13:842651. (第一作者)
10. Wang S, Lu M, Zhao Z, et al. Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study. Sci Rep. 2021; 11(1):17746. (通讯作者)
11. Wang H, et al. Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis. Cytokine. 2021; 138:155391. (通讯作者)
12. Liu Y, et al. Single-cell profiling reveals divergent, globally patterned immune responses in murine skin inflammation. iScience. 2020;23(10):101582. （第一作者)
13. Liu J, Liu Y, et al. TWEAK/Fn14 signals mediate burn wound repair. J Invest Dermatol. 2019;139(1):224-234. (共一作者)
14. Liu Y, et al. TWEAK factor-inducible 14 activation participates in Ro52-mediated photosensitization in cutaneous lupus erythematosus. Front Immunol. 2017, 8:651. (第一作者)
15. Liu Y, et al. BP180 is critical in the autoimmunity of bullous pemphigoid. Front Immunol. 2017; 8:1752. (第一作者)
16. Liu Y, et al. TWEAK/Fn14 activation contributes to the pathogenesis of bullous pemphigoid. J Invest Dermatol. 2017, 137(7):1512-1522. (第一作者)
17. Liu Y, et al. A transcription factor 7-like 1-lipocalin 2 axis in the differentiation of keratinocytes. Cell Death Dis. 2016; 7(6): e2241. (第一作者)
18. Liu X, Liu Y, Xu M, et al. Zinc finger protein A20 is involved in the anti-psoriatic effect of calcipotriol. Br J Dermatol. 2016; 175(2): 314-324. (共一作者)