Layer-by-layer micromolding of natural biopolymer scaffolds with intrinsic microfluidic networks
发布时间：2025-04-30
点击次数：
- 发布时间：
- 2025-04-30
- 论文名称：
- Layer-by-layer micromolding of natural biopolymer scaffolds with intrinsic microfluidic networks
- 发表刊物：
- Biofabrication（影响因子：4.289）
- 摘要：
- Three-dimensional (3D) microfluidic network plays an important role in engineering thick organs. However, most of the existing methods were limited to mechanically robust synthetic biomaterials and only planar or simple microfluidic networks have been incorporated into soft natural biopolymers. Here we presented an automatic layer-by-layer micromolding strategy to reproducibly fabricate 3D microfluidic porous scaffolds directly from the aqueous solution of soft natural biopolymers. Process parameters such as liquid volume for each layer and contact displacement were investigated to produce a structurally stable 3D microfluidic scaffold. Microscopic characterization demonstrated that the microfluidic channels were interconnected in 3D and successfully functioned as a convective pathway to transport a polymer solution. Endothelial cells grew relatively well in the porous microfluidic channels. It is envisioned that this method could provide an alternative way to reproducibly build complex 3D microfluidic networks into extracellular matrix-like scaffolds for the fabrication of soft vascularized organs.
- 合写作者：
- Jiankang He, Ye Wang et al.
- 是否译文：
- 否
- 发表时间：
- 2013-01-14