Factors on trough teicoplanin levels, associations between levels, efficacy and safety in patients with gram-positive infections
发布时间：2025-04-30
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- 发布时间：
- 2025-04-30
- 论文名称：
- Factors on trough teicoplanin levels, associations between levels, efficacy and safety in patients with gram-positive infections
- 发表刊物：
- International Journal of Clinical Pharmacology and Therapeutics
- 摘要：
- Abstract
OBJECTIVE:
The objective of this study was to identify the factors influencing trough teicoplanin concentrations (Cmin), to investigate the relationship between teicoplanin Cmin with efficacy and safety, and to determine a target therapeutic concentration.
METHODS:
An analysis was performed on 95 serum concentrations from 50 patients with gram-positive infections who received teicoplanin treatment. Teicoplanin serum concentrations were measured by high-performance liquid chromatography. Univariate and multivariable analysis were performed to investigate the effect of independent variables on teicoplanin Cmin. A logistic regression analysis was used to determine the relationship between teicoplanin Cmin and efficacy and safety.
RESULTS:
Teicoplanin therapy was effective in 74.0% (37/50) of patients, and 10.0% (5/50) of patients exhibited signs of adverse events. Using multivariable linear regression, two covariates were found to be a significant effect on teicoplanin Cmin: dosage (mg/kg), and creatinine clearance rate (CLcr). There was no covariate that has a significant impact on the safety of teicoplanin and only teicoplanin Cmin has a significant impact on the efficacy of treatment in the logistics regression. The logistics regression analysis showed that teicoplanin Cmin of 10 mg/L was associated with a 79.4% probability of success response.
CONCLUSIONS:
This study highlighted that teicoplanin Cmin was strongly influenced by the values of dosage (mg/kg) and CLcr and the teicoplanin Cmin range of 10 â 20 mg/L was identified as the therapeutic target with optimum clinical efficacy and safety.
- 合写作者：
- Taotao Wang, Yalin Dong*
- 是否译文：
- 否
- 发表时间：
- 2015-05-01
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