Date:

2025-04-30

Title of Paper:

Plasmonic Spectral Detection of Carcinoembryonic Antigen by Preventing the Direct Binding of Rhodamine 6G with Au Nanoparticles

Journal:

Plasmonics

Summary:

Abstract Carcinoembryonic antigen (CEA) was used as a
separator to prevent the Rhodamine 6G (R6G)-induced aggregation
of colloidal gold nanoparticles. The destroyed
aggregation has been monitored by measuring the absorption
and resonance light scattering peaks corresponding to
the longitudinal surface plasmon resonance (SPR) of the
chain-like aggregated gold nanoparticles (AuNPs). It was
found that the pre-adding of CEA with different concentrations
to the gold colloids before mixing them with R6G
could lead to the longitudinal SPR peak decrease and blue
shift. By analysing the intensity changing and wavelength
shifting of the absorption spectra, CEA could be detected in
a linear range from 0.2 to 4 ng/mL, and the limit of detection
reaches to 0.1 ng/mL. The sensitivity of the CEA concentration
dependent shifting and quenching of the plasmonic
absorption and scattering corresponding to the AuNPs aggregation
presents a well potential application of biologic
spectral sensing.

Co-author:

Jian Zhu, Hong-wen Gao, Jian-jun Li, Jun-wu Zhao

Translation or Not:

No

Date of Publication:

2013-05-11