Date:

2025-04-30

Title of Paper:

Optimizing the plasmonic sensing of RNA folding based on local refractive index change of gold nanorod

Journal:

Applied Surface Science

Summary:

In this paper, we investigate the spectroscopic sensing of RNA folding based on surface plasmon resonance
(SPR) in coated gold nanorod. Theoretical calculations indicate that the folding and unfolding of coating
RNA lead to the changing of local surrounding refractive index (RI) of gold nanorod, and then result in
obvious SPR shift of absorption spectrum. The SPR shift is shown to be strongly influenced by the changing
of the RNA length, environmental media and aspect ratio (AR) of gold nanorod. The high plasmonic
sensitivity can be obtained with a long RNA length, great AR and large dielectric constant (DC) difference
between RNA shell and environmental media. This new plasmonic sensing picture corresponding to
folding and unfolding process of RNA is effective guide for the design and fabrication of nanometer scale
biosensor for conformational probing of RNA.
© 2012 Elsevier B.V. All rights reserved.
Applied Surface Science 275 (2013) 264– 268

Co-author:

Jian Zhu, Jian-jun Li, Jun-wu Zhao

Translation or Not:

No

Date of Publication:

2013-01-01