Deformability considerations in filtration of biological cells
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发布时间：2025-04-30
发布时间：2025-04-30
论文名称：Deformability considerations in filtration of biological cells
发表刊物：Lab on A Chip
摘要：Biological cells are highly sensitive to variation in local pressure because cellular membranes are not rigid. Unlike microbeads, cells deform under pressure or even lyse. In isolating or enriching cells by mechanical filtration, pressure-induced lysis is exacerbated when high local fluidic velocity is present or when a filter reaches its intended capacity. Microfabrication offers new possibilities to design fluidic environments to reduce cellular stress during the filtration process. We describe the underlying biophysics of cellular stress and general solutions to scale up filtration processes for biological cells.
合写作者：Jason S Kuo, Yongxi Zhao, et al.
是否译文：否
发表时间：2010-03-30