西安交通大学教师主页管理系统谢勇 Dynamical mechanisms for sensitive response of aperiodic firing cells to external stimulation Home

Dynamical mechanisms for sensitive response of aperiodic firing cells to external stimulation

Release Time:2025-04-30

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Title of Paper:: Dynamical mechanisms for sensitive response of aperiodic firing cells to external stimulation

Summary:: An interesting phenomenon that aperiodic firing neurons have a higher sensitivity to drugs than periodic firing
neurons have been reported for the chronically compressed dorsal root ganglion neurons in rats. In this study, thedynamical mechanisms for such a phenomenon are uncovered from the viewpoint of dynamical systems theory. We use the Rose–Hindmarsh neuron model to illustrate our opinions. Periodic orbit theory is introduced to characterize the dynamical behavior of aperiodic firing neurons. It is considered that bifurcations, crises and sensitive dependence of chaotic motions on control parameters can be the underlying mechanisms. And then, a similar analysis is applied to the modified Chay model describing the firing behavior of pancreatic beta cells. The same dynamical mechanisms can be obtained underlying that aperiodic firing cells are more sensitive to external stimulation than periodic firing ones. As a result, we conjecture that sensitive response of aperiodic firing cells to external stimulation is a universal property of
excitable cells.