A Fluorenone Alkaloid from Caulophyllum robustum Maxim. with Anti-myocardial Ischemia Activity
Title of Paper:
A Fluorenone Alkaloid from Caulophyllum robustum Maxim. with Anti-myocardial Ischemia Activity
Summary:
A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6- dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
Co-author:
Wang SC, Wen BY, Wang L, Liu JT, He LC
Papers
