Cotton gauze fabricated with hydro-stable Zn-MOF enables hemostasis acceleration, antibacterial activity, and wound regeneration
Title of Paper:
Cotton gauze fabricated with hydro-stable Zn-MOF enables hemostasis acceleration, antibacterial activity, and wound regeneration
Journal:
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Summary:
Cotton has long been regarded as a naturally abundant and clinically indispensable material for medical textiles. Cotton gauze, a cornerstone material in wound management due to its inherent fluid absorption capacity, faces limitations in simultaneously addressing hemorrhage and infection. In this work, we developed a multifunctional wound dressing by functionalizing commercial cotton gauze with a tannic acid-assisted layer-by-layer assembly strategy to immobilize zinc-based metal-organic frameworks (Zn-BDC). The resulting cg@PTA@Zn-BDC-5 dressing synergizes the intrinsic advantages of cotton textiles with advanced functionalities, achieving a 76.4 % reduction in blood clotting time through Zn2+-activated coagulation cascades and enhanced platelet adhesion (73.6 % red blood cell attachment). Crucially, the modified cotton gauze also exhibits broad-spectrum antibacterial activity (>95 % inhibition against E. coli and S. aureus), addressing the dual demands of hemostasis and infection prevention unmet by conventional cotton dressings. Biosafety assessments confirm clinical viability (<3 % hemolysis, similar to 90 % cell viability). In vivo studies demonstrate accelerated wound closure through Zn2+-mediated collagen deposition and anti-inflammatory modulation, with the cotton scaffold synergistically enables therapeutic amplification due to its mechanical compliance, breathability and fluid management capabilities.
Co-author:
Sheng Kangjia; Zheng Xinglong; Ren Jiawei; Gao Yan; Long Jiao; Wang Zhaojia; Lu Lu; Bao Tao*; Wang Sicen*
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