Hybrid biointerface engineering nanoplatform for dual-targeted tumor hypoxia relief and enhanced photodynamic therapy
Title of Paper:
Hybrid biointerface engineering nanoplatform for dual-targeted tumor hypoxia relief and enhanced photodynamic therapy
Journal:
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Summary:
The clinical application of photodynamic therapy (PDT) is limited by the lack of tumor selectivity of photo-sensitizer (PS) and the hypoxic tumor microenvironment (TME). To address these limitations of PDT, we developed a hybrid engineered biointerface nanoplatform that integrated anti-epidermal growth factor receptor (EGFR)-aptamer (EApt)-modified liposomes with tumor cell membranes (TMs) to create M/L-EApt. M/L-EApt exhibited enhanced stability and significant dual-targeting ability, enabling selectively accumulate in hypoxic
Co-author:
Xueyan Zhen, Lanlan Jia, Qingyu Tang, Ying Zhao, Peishan Li, Jing Li, Xiaoyu Xie*, Sicen Wang*
Papers
