Engineering biomimetic graphene nanodecoys camouflaged with the EGFR/HEK293 cell membrane for targeted capture of drug leads
Title of Paper:
Engineering biomimetic graphene nanodecoys camouflaged with the EGFR/HEK293 cell membrane for targeted capture of drug leads
Summary:
Advanced graphene (G)-based nanomaterials have risen as emerging stars for biomedical applications
over the past decade due to their unique physicochemical properties. However, the preparation of
G-based nanomaterials with satisfactory bioactivity to meet the growing demands of multitasking applications in biocomplexity systems remains a challenge. Herein, we presented a biomimetic route to modify
graphene oxide (GO) using high expression epidermal growth factor receptor cell membrane (CM).
Owing to the inherent properties of the CM for multifaceted interaction with active ligands, the well
camouflaged GO could capture the drug leads with targeting properties. The as-prepared CM-coated
magnetic GO exhibited excellent binding properties, including good selectivity, high adsorption capacity,
and suitable adsorption rates. In addition, by coupling this assay with mass spectrometry, two potential
bioactive compounds, luteolin and caffeic acid, were screened from Taraxacum mongolicum Hand.-
Mazz. It is anticipated that this biomimetic approach can open new possibilities for the rational design of
improved G-based biocomposites and extend their bioapplications.
Co-author:
Q Hu, XL Zhang, LL Jia, XY Zhen, XY Pan, XY Xie*, SC Wang*
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