发布时间：2025-04-30

论文名称：Multifunctional Polyphosphazene-Coated Multi-Walled Carbon Nanotubes for the Synergistic Treatment of Redox-Responsive Chemotherapy and Effective Photothermal Therapy

发表刊物：Polymer Chemistry

摘要：It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent foreffective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligiblyaffected normal cells. Hence, this DDS demonstrates the proof-ofconcept for effective chemo-photothermal synergistic therapy

合写作者：Wang Daquan#; Ren Yibo#; Shao Yongping; Meng Lingjie*

卷号：8(45)

页面范围：6938-6942

是否译文：否

发表时间：2017-10-01