Special Issue "Nanozyme for Biosensing"

Dear Colleagues,

Enzymes have played a central role in biosensor development. The excellent substrate specificity and fast turnover rates make enzymes an ideal component in target recognition and/or signal transduction. However, protein enzymes are prone to irreversible denaturation and it is difficult to perform enzyme-based assays under harsh conditions such as high temperature, extreme pH, or high ionic strength. To solve these problems, the robust artificial enzymes have been developed to replace protein enzymes in designing bioassays. A recent example is using nanomaterials with intrinsic enzyme-like activity (nanozymes). Since the pioneering work by Yan and coworkers in 2007, nanozymes with diverse enzyme-like activities have been identified and are widely used in biomedicine. Compared to protein enzymes, nanozymes are more cost-effective, more stable, and showing versatile surface functionalities. The research in this field will provide useful tools for biomedical and environmental applications. The Topic Editors sincerely welcome Original Research, Review articles, and Perspectives with a focus on using nanozymes to develop biosensors for disease diagnosis, environmental monitoring, and food safety.

Potential topics include but are not limited to the following:

-Design and synthesis of novel nanomaterials (metal, metal oxide, carbon, metal-organic framework etc) with enzyme-like activities and its applications in biosensing; investigating the structure-performance relationships of nanozymes towards more controllable activities;

-Surface modification of nanozymes with small molecules, polymers or biomolecules towards more specific and/or sensitive biosensors;

-Design nanozyme-nanozyme or nanozyme-protein cascades to expand the applications to nanozymes in biosensing;

-Design stimuli-responsive nanozymes, such as temperature, pH, small biological molecules, enzymes, and/or nucleic acids;

-Integrating nanozymes with the other nanomaterials to achieve multiple functions;

-Fabricating optical, electrical, magnetics biosensor for detection of cancer biomarkers, environmental toxins, and/or food contaminants.

Linke：https://www.mdpi.com/journal/biosensors/special_issues/nanozyme_biosens