Characterization, physicochemical properties and biocompatibility
Release Time:2025-04-30
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- Date:
- 2025-04-30
- Title of Paper:
- Characterization, physicochemical properties and biocompatibility
- Journal:
- Acta Biomaterialia (2010年 IF=4.822)
- Summary:
- Abstract: In this study, physicochemical properties and biocompatibilities of the La-containing apatites were intensively investigated together with their characterizations in composition, structure and morphology by using X-ray Diffraction (XRD), Flourier-Transformed Infrared (FTIR) spectra, Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray Spectroscopy (EDXS), respectively. The results demonstrate that the La3+ ion can be incorporated into the crystal lattice of hydroxyapatite (HA) with a product of La-containing apatites (LaxCa10-x(PO4)6(OH)2+x-2yOy□y-x (x≦0.5, y<1+x/2) or LaxCa10-x(PO4)6Oy□y-x (0.5<x<2, y=1+x/2)) through a high-temperature solid phase synthesis. At La contents lower than 20%, the product is composed of the major phase, Lax-OAP, besides a trifle of tricalcium phosphate (TCP), but at a La content of 20%, the product is pure La-containing oxyapatite with a formula of La2Ca8(PO4)6O2 (La2-OAP, x=2, y=2). It is also found that the La content plays important roles in the physicochemical properties and biocompatibilities of the La-containing apatites. By contrast with the La-free apatite, the La-containing apatites possess a series of attractive properties including higher thermal stabilities, higher flexural strengths, lower dissolution rates, larger alkaline phosphatase activities (ALP), preferable osteoblast morphologies and comparable cytotoxicities. Particularly, the sintered La-containing apatite block achieves a maximal flexure strength of 66.69MPa±0.98MPa at 5% La content (cc=0.95), increased by 320% in comparison with the La-free apatite. The present study suggests the La-containing apatite possesses potential applications in developing a new type of bioactive coating material for the metal implants and also a hopeful La carrier for exploring the beneficial functions of La in human body.
- Co-author:
- Guo Dagang, Wang Aohan, Han Yong, Xu Kewei
- Volume:
- 9(5)
- Page Number:
- 3512-3523
- Translation or Not:
- No
- Date of Publication:
- 2009-08-12