Physicochemical properties of TTCP/DCPA system cement formed in physiological saline solution and its cytotoxicity
Release Time:2025-04-30
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- Date:
- 2025-04-30
- Title of Paper:
- Physicochemical properties of TTCP/DCPA system cement formed in physiological saline solution and its cytotoxicity
- Journal:
- J Biomed Mater Res （2010年IF =3.044）
- Summary:
- Abstract The physicochemical properties and cytotoxicity of calcium phosphate cement (CPC) prepared by mixing cement powders of tetracalcium phosphate (TTCP) and dicalcium phosphate (DCPA) with a cement liquid of physiological saline solution were investigated in this paper. The microstructure evolutions of the hardened cement and hydration crystals as a function of immersion time in similar physiological fluids such as physiological saline solution (0.9%NaCl) and simulated body fluids (SBF) were also studied. Results show that the setting time of this CPC is in range of 12~15min which can meet the demands for clinical application and that the mean compressive strength of the CPC samples immersed in SBF for three days is 104±10MPa and its maximal value is 115MPas. It reaches the transverse compressive strength of human long bone, 106~133MPa. Both the results of the X-ray powder diffraction analyses (XRD) and scanning electron microscopy (SEM) observation indicate that the reinforcing effect of residual TTCP particles in the early stages of immersion is mainly responsible for the increase in the initial strength. The initial reinforcing effect of TTCP particles provides advantages for clinical application, where the material is loaded from the very beginning of the implantation or especially a certain initial strength is required in the first stages of the implantation, though they fail to keep this high level when continuously immersed for a longer time. The cytotoxicity results show the relative growth rate (RGR%) of the CPC samples using physiological saline solution as a cement liquid is superior to that of the pastes using the 0.5mol/l phosphate acid solution as the cement liquid and this is caused by the pH difference between the two CPC pastes.
Key words: Calcium phosphate cemment (CPC); immersion process; physiological saline solution (0.9% NaCl); cytotoxicity
- Co-author:
- Guo Dagang, Xu Kewei, Sun Haoliang, Han Yong.
- Volume:
- 77A(2)
- Page Number:
- 313–323
- Translation or Not:
- No
- Date of Publication:
- 2004-07-24