Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo Photothermal Cancer Treatment
发布时间：2025-04-30
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- 发布时间：
- 2025-04-30
- 论文名称：
- Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo Photothermal Cancer Treatment
- 发表刊物：
- BIOCONJUGATE CHEMISTRY
- 摘要：
- We developed a bifunctional nanoplatform for targeted synergistic chemo-photothermal cancer treatment. The nanoplatform was constructed through a facile method in which poly(N-vinyl pyrrole) (PVPy) was coated on cut multiwalled carbon nanotubes (c-MWNTs); FA-PEG-SH was then linked by thiol-ene click reaction to improve the active targeting ability, water dispersibility, and biocompatibility and to extend the circulation time in blood. The PVPy shell not only enhanced the photothermal effect of c-MWNTs significantly but also provided a surface that could tailor targeting molecules and drugs. The resulting MWNT@ PVPy-S-PEG-FA possessed high drug-loading ratio as well as pH sensitive unloading capacity for a broad-spectrum anticancer agent, doxorubicin. Owing to its outstanding efficiency in photothermal conversion and ability in targeted drug delivery, the material could potentially be used as an efficient chemo-photothermal therapeutic nanoagent to treat cancer.
- 合写作者：
- Wang, Daquan; Ren, Yibo; Shao, Yongping; Yu, Demei; Meng, Lingjie
- 是否译文：
- 否
- 发表时间：
- 2017-11-01