陈莉娜
- 教授
- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- E-Mail:
- Date of Employment:2006-12-28
- Education Level:With Certificate of Graduation for Doctorate Study
- Professional Title:教授
- Status:Employed
- Alma Mater:西安交通大学
- College:School Of Basic Medical Sciences
- Discipline:Pharmaceutical Science
- Papers
Ghrelin对糖尿病大鼠心肌动作电位和瞬时外向钾电流的影响
Release Time:2025-04-30 Hits:
- Date:2025-04-30
- Title of Paper:Ghrelin对糖尿病大鼠心肌动作电位和瞬时外向钾电流的影响
- Journal:西安交通大学学报(医学版)
- Summary:目的探讨外源性ghrelin对糖尿病心肌病(DCM)大鼠心肌动作电位及瞬时外向钾电流(Ito)的影响。方法雄性SD大鼠腹腔注射链脲佐菌素(60mg/kg)诱导Ⅰ型DCM模型,并采用全细胞膜片钳技术观察ghrelin对糖尿病大鼠心室肌细胞动作电位及瞬时外向钾电流的影响。结果与DCM组比较,10~(-7) mmol/L ghrelin明显延长DCM大鼠心室肌细胞5%动作电位时程(APD50)[(12.49±2.32)%;n=7,P=0.037]及APD90[(26.29±5.13)%;n=7,P=0.006];并明显抑制Ito电流峰值,抑制率[(23.14±3.07)%;n=9,P=0.021]。结论外源性ghrelin抑制Ito电流而延长DCM大鼠心肌动作电位时程,参与糖尿病大鼠心脏电生理的重构。
- Co-author:冯丹阳, 孙强, 陈莉娜, 赵正杭, 周筠
- Volume:38(5)
- Page Number:661-664
- Translation or Not:No
- Date of Publication:2017-05-01