发布时间：2025-04-30

论文名称：20. Time-varied characteristics of acupuncture effects in fMRI studies

发表刊物：Human Brain Mapping

摘要：When studying the neural responses to acupuncture with a block-designed paradigm, its
temporal dynamics predicted by the general linear model (GLM) conforms to typical ‘‘on-off’’ variations
during a limited period of the experiment manipulation. Despite a lack of direct evidence associating
its psychophysiological response, numerous clinical reports suggest that acupuncture can
provide pain relief beyond a needling session. Therefore, a typical GLM analysis may be insensitive or
inappropriate for identifying altered neural responses resulting from acupuncture. We developed a
new approach to investigate the dynamics underlying sustained effects of acupuncture. Specifically,
we designed two separate models to evaluate the baseline activities (prior to stimulation) and neural
activities in sequential epochs, using three block-designed functional runs: acupuncture at acupoint
ST36, nonmeridian point (NMP) stimulation, and a visual task. We found that the activity patterns

合写作者：Bai L（第一作者），et al.

卷号：30(11)

页面范围：3445-3460

是否译文：否

发表时间：2009-12-14